专利号:US-6229055-B1 优先权日:1996-04-12 标题 :Synthesis of fluorinated xanthene derivatives 发明人:KLAUBERT DIETER H; GEE KYLE R 权利人:MOLECULAR PROBES INC 摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
专利号:WO-9840512-A2 优先权日:1997-03-13 标 题 :Transglycolytic synthesis of branched oligosaccharides
专利号:EP-0968301-A2 优先权日:1997-03-13 标题:Transglycolytic synthesis of branched oligosaccharides
专利号:US-5756712-A 优先权日:1997-01-23 标题:Peptidodisaccharides as oligosaccharide mimetics 发明人:SABESAN SUBRAMANIAM 权利人:DU PONT 摘要:Methods are provided to replace the ether oxygen linkage of oligosaccharides with a peptide link, -NHC(O)-, where the nitrogen atom is linked to the anomeric carbon atom of the sugar. A new family of building blocks for combinational synthesis, peptidodisaccharides, is provided containing the peptide linkage. Synthesis is more facile than with the oxygen-linked carbohydrates; the resulting compounds are expected to be more stable to enzymatic and chemical hydrolysis and to be amenable to automated synthesis.
专利号:WO-0004007-A1 优先权日:1998-07-17 标 题 :Fluorescent dibenzazole derivatives and methods related thereto 发明人:BROWN LAUREN R; XU CHENG 权利人:PROMEGA BIOSCIENCES INC 摘要:Dibenzazole compounds having general structure (I and II), wherein: R1, R2, R3, R4, R5, R6 are independently H or a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety; Y is H or a cleavable moiety; X is a hydrogen, halogen, CF3, or SO3H; V and W are oxygen or sulfur; Z is -C=C-, -C C- or an aromatic ring moiety; and n is 0, 1, or 2. When n=0 at least one of R1, R2, R3, R4, and R5 is a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety or X is a halogen, CF3 or SO3H. These compounds are highly fluorescent and can be easily detected using a fluorometer. Derivatives in which the Y group is a substituent other than H contain a fluorescence inhibiting chemical moiety that upon removal restores the fluorescence of the compound. Methods for their synthesis and application are provided.
专利号:US-6140051-A 优先权日:1997-07-21 标 题:Fluorescent dibenzazole derivatives and methods related thereto 发明人:BROWN LAUREN R; XU CHENG 权利人:PROMEGA BIOSCIENCES INC 摘要:Dibenzazole compounds having the general structure: wherein; R1, R2, R3, R4, R5, R6 are independently H or a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety; Y is H or a cleavable moiety; X is a hydrogen, halogen, CF3, or SO3H; V and W are oxygen or sulfur; Z is -C=C-, -C 3BOND C- or an aromatic ring moiety; and n is 0, 1, or 2. When n=0 at least one of R1, R2, R3, R4, and R5 is a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety or X is a halogen, CF3 or SO3H. These compounds are highly fluorescent and can be easily detected using a fluorometer. Derivatives in which the Y group is a substituent other than H contain a fluorescence inhibiting chemical moiety that upon removal restores the fluorescence of the compound. Methods for their synthesis and application are provided.
参考标题:Streptococcus Pneumoniae Type Xiv Polysaccharide: Synthesis Of A Repeating Branched Tetrasaccharide With Dioxa-Type Spacer-Arms 作者:Paul-Henri Amvam-Zollo,Pierre Sinaÿ |发布日期:1986.8 摘要:Beta-Glycosides Of 2-Acetamido-2-Deoxy-D-Glucopyranose Were Synthesised, Using Either 7-Methoxycarbonyl-3,6-Dioxa-1-Heptanol Or 8-Azido-3,6-Dioxa-1-Octanol. Selective Beta-Lactosylation Of 7-Methoxycarbonyl-3,6-Dioxaheptyl 2-Acetamido-3-O-Benzyl-2-Deoxy-Beta-D-Glucopyranoside With Hepta-O-Acetyl-Lactosyl-Trichloroacetimidate, Followed By Beta-Galactosylation Of The Secondary Hydroxyl Group With O-(2
合成参考文献
摘要:Kryczka, B.; Lewkowski, J.; Zawisza, A., Science of Synthesis, (2007) 29, 992. 摘要:Kryczka, B.; Lewkowski, J.; Zawisza, A., Science of Synthesis, (2007) 29, 1027. 摘要:Robina, I.; Vogel, P., Science of Synthesis, (2008) 37, 800.