CAS: 465-11-2; 5-[(3S,5R,8R,9S,10S,11R,13R,14S,17R)-3,11,14-Trihydroxy-10,13-Dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-Tetradecahydrocyclopenta[a]Phenanthren-17-Yl]Pyran-2-One
该化合物是一种来自Thoad Bufo gargarizans毒液的生物活性bufedienolide化合物,它具有很强的细胞毒性和抗沙素特性,成为药理研究的一个主题.Gamabufotolin通过诱发血细胞癌和白血病,在抑制癌症细胞,特别是肝细胞癌和白血病扩散方面表现出了效力.它的机制包括调节关键信号路径,包括PI3K/AKT和MAPK.此外,它显示出作为抗炎剂和心血管剂的潜力.在治疗剂量方面,它具有很高的特性和低毒性,因此,Gamabufotalin是进一步发展肿瘤和其他治疗应用的有前途的候选者.
- 英文名称5-[(3S,5R,8R,9S,10S,11R,13R,14S,17R)-3,11,14-Trihydroxy-10,13-Dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-Tetradecahydrocyclopenta[a]Phenanthren-17-Yl]Pyran-2-One
- 中文名称日本蟾蜍毒苷元
- 其它别名5b-Bufa-20,22-dienolide, 3b,11a,14-trihydroxy- (7CI,8CI); Gamabufotalin (6CI); Gamabufagin; Gamabufogenin; Gammabufotalin
- CAS编号465-11-2
- MFCD编号:MFCD01740822
- FDA UNII编号:5HH3KM165O
- 分子式:C24H34O5分子量:402.52
- 产品CID: 1463028
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
- 警示词Warning
- 危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399002-1,4-丁二醇
2905141000-异丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2024109742-A1
优先权日:2022-11-21
标题:Method for efficiently synthesizing bufadienolides and derivatives thereof
发明人：LIN GUOQIANG; YE WENBO; ZHAO QUNFEI; ZHANG JIANGE; HE QINGLI; WANG CHAO; YU SHAOPENG
权利人:UNIV SHANGHAI TRADITIONAL CHINESE MEDICINE
摘要:Disclosed in the present invention is a method for efficiently synthesizing bufadienolides and derivatives thereof. By starting from cheap and easily-available androstenedione 4-AD, the method performs bio-enzyme oxidization on same to obtain 14-α-hydroxy-androstane-17-one compounds, then completes loading of E-ring pyrone by using chemical conversion without any protective group so as to obtain a key intermediate, and achieves synthesis of bufadienolides by starting from the key intermediate. The method synthesizes resibufogenin in just eight operation steps, has simple and short route, simple operations and large reaction scale, can be used for large-scale preparation of such natural products, and has use prospects in industrial production.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Die Herzwirksamen Glykoside, Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963, -(191), 1963
参考文献:10.1007/s00216-018-1097-4
摘要:Ren W, Han L, Luo M, Bian B, Guan M, Yang H, Han C, Li N, Li T, Li S, Zhang Y, Zhao Z, Zhao H. Multi-component identification and target cell-based screening of potential bioactive compounds in toad venom by UPLC coupled with high-resolution LTQ-Orbitrap MS and high-sensitivity Qtrap MS. Analytical and Bioanalytical Chemistry. 2018 Apr 28;410(18):4419–35. doi: 10.1007/s00216-018-1097-4.
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