CAS: 4022-81-5; 1-(4-Chlorophenyl)Biguanide Hydrochloride

该化合物是一种合成重聚物衍生物,可用于制药和化学研究,其结构特征是附于大原体骨的氯联苯组,增强了其活性和绑定性.该化合物通常用作生物活分子合成的中间体,包括抗糖尿病和抗微生物剂.盐的形态可以提高溶性性和稳定性,便于处理和储存.其高纯度和一贯性使其适合精确研究和开发.该化合物的界定明确的化学特性允许合成途径的可靠性能,有助于其在药用化学和药物发现中的效用.

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CAS号106-47-8 对氯苯胺 | CAS号500-42-5 氯拉扎尼 | CAS号516-21-2 Cycloguanil | CAS号30355-61-4 6-(氯甲基)-n-(4-氯苯... | CAS号16018-51-2 N-(4-氯苯基)-n-(4,... | CAS号30805-25-5 1-(4-chlorophen... | CAS号152-53-4 环氯胍 | CAS号672-93-5 2-N-(4-chloroph... | CAS号645-18-1 2-N-(4-chloroph... | CAS号5405-65-2 N-(4-chlorophen...

合成工艺路线路线简述

    📜1-苯基双胍置于双氧水,Sodium Chloride,Chloroperoxidase体系中,用 Aq. Phosphate Buffer 作为反应溶剂,以68 %的收率获得产物1-(4-氯苯基)双胍盐酸盐
    参考文献:Improved Enzyme-Assisted Synthesis Of Chlorhexidine Base
    标题:Improved Enzyme-Assisted Synthesis Of Chlorhexidine Base
    摘要:The Present Disclosure Provides A Method For Preparing Chlorhexidine,Salts Thereof,Or Hydrates Thereof,Wherein The Method Comprises An Enzymatic Chlorination,A Coupling Step,Or A Combination Thereof. The Disclosure Further Includes Compositions Comprising Chlorhexidine Prepared By The Disclosed Methods.

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    专利信息


    专利号:WO-2024155314-A1
    优先权日:2023-01-18
    标 题:Improved enzyme-assisted synthesis of chlorhexidine base
    发明人：JAIN PRAJAKTA; JAIN RATNESH; KHARE LALIT
    权利人:XTTRIUM LABORATORIES INC
    摘要:The present disclosure provides a method for preparing chlorhexidine, salts thereof, or hydrates thereof, wherein the method comprises an enzymatic chlorination, a coupling step, or a combination thereof. The disclosure further includes compositions comprising chlorhexidine prepared by the disclosed methods.

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    主要参考文献

    参考标题:Synthesis And In Vitro Anticancer Evaluation Of Some 4,6-Diamino-1,3,5-Triazine-2-Carbohydrazides As Rad6 Ubiquitin Conjugating Enzyme Inhibitors
    作者:Hend Kothayer,Sebastian M. Spencer,Kaushlendra Tripathi,Andrew D. Westwell,Komaraiah Palle |发布日期:2016.4
    摘要:Abbreviate Our Compound Names As 'New Triazines', Have Been Synthesized, Based On The Previously Reported Rad6B-Inhibitory Diamino-Triazinylmethyl Benzoate Anticancer Agents Tz9 And 4-Amino-N'-Phenyl-6-(Arylamino)-1,3,5-Triazine-2-Carbohydrazides. Synthesis Of The Target Compounds Was Readily Accomplished In Two Steps From Either Bis-Aryl/aryl Biguanides Via Reaction Of Phenylhydrazine Or Hydrazinehydrate

    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#04062
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