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专利信息
专利号:US-8071132-B2
优先权日:2004-06-01
标 题:Unagglomerated core/shell nanocomposite particles
发明人:ADAIR JAMES H; ROUSE SARAH M; WANG JUN; KESTER MARK; SIEDLECKI CHRISTOPHER; WHITE WILLIAM B; VOGLER ERWIN; SNYDER ALAN; PANTANO CARLO G; RUIZ-VELASCO VICTOR; SINOWAY LAWRENCE
权利人:ADAIR JAMES H; ROUSE SARAH M; WANG JUN; KESTER MARK; SIEDLECKI CHRISTOPHER; WHITE WILLIAM B; VOGLER ERWIN; SNYDER ALAN; PANTANO CARLO G; RUIZ-VELASCO VICTOR; SINOWAY LAWRENCE; PENN STATE RES FOUND
摘要:The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.
专利号:US-7078406-B2
优先权日:2001-10-09
标 题 :Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
发明人:CARVER JR THEODORE E; RINKER JAMES M
权利人:JOHNSON & JOHNSON PHARM RES
摘要:The present invention is directed to a compound of Formula I: n nwherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.
专利号:US-9149445-B2
优先权日:2009-07-27
标 题:Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
发明人:LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS
权利人:LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS; UNIV PRINCETON
摘要:A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme.
专利号:MX-PA04003451-A
优先权日:2001-10-09
标 题:SUBSTITUTED DIFENYLOXAZOLS, THE SYNTHESIS OF THE SAME AND THE USE OF THE SAME AS FLUORESCENCE DETECTORS.