CAS: 35264-07-4; Boc-Allo-Ile-Oh

该化合物是氨酸异丙酮的衍生物,其特点是氨基氨基酸组中存在一种乙基丁基氧碳酸(Boc)保护性(Boc)保护性碳酸(Boc),该化合物一般用于浸酸酯合成和研究,因为它能够在化学反应期间保护氨基组,允许其他功能组有选择地进行修改.Boc-L-Aloisolecine是一种非极性,水分恐惧性氨基酸,它影响注入该物质的和蛋白质的折叠和稳定性,其结构包括一个分支侧链,与其他氨基酸相比,它具有独特的特性.在酸性条件下可以清除该物质,从而便利形成符合预期序列的.与许多氨基酸衍生物一样,Boc-L-Aloisoolecine被用于各种生物化学应用,包括药物开发和蛋白相互作用研究.正确处理和储存条件对于在实验室环境中保持其稳定性和再活动至关重要.

结构式图片

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L-isoleucine tert-butoxycarbonyloxy-6-chloro-1H-benzotriazole1-tert-butoxycarbonyloxy-6-chloro-1H-benzotriazole tert-butyl alcoholtert-butyl alcohol tert-butyl dicarbonatedi-tert-butyl dicarbonateε-Z-Lys-°CH3)B°C-Ileu-(Nε-Z-Lys-°CH3) tert-(butoxycarbonyl)isoleucine succinimidyl ester N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester 2-{(R)-1-[(2S,3S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-2-phenyl-ethyl}-thiazole-4-carboxylic acid methyl ester

合成工艺路线路线简述

    📜(S)-2,2-Dimethyl-4-((R)-1-Methyl-Prop-2-Ynyl)-Oxazolidine-3-Carboxylic Acid Tert-Butyl Ester置于platinum(Iv) Oxide 重铬酸吡啶,氢气,4-甲基苯磺酸吡啶体系中,化学反应生成 Boc-L-别异亮氨酸
    参考文献:1,3-非对映体与溴代烯类的控制.对映体纯的β-支链α-氨基酸的合成
    标题:1,3-非对映体与溴代烯类的控制.对映体纯的β-支链α-氨基酸的合成
    摘要:衍生自(d)-丝氨酸的溴代烯3A和3B用有机铜试剂进行s N 2'烷基化,得到炔基氨基醇衍生物.这些化合物可以进一步转化为对映体富集的支链α-氨基酸,例如(l)-异亮氨酸和(l)-异苏氨酸.
    DOI:10.1016/0040-4039(94)80115-0

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    专利信息


    专利号:US-6812350-B2
    优先权日:2002-06-04
    标题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
    发明人：HULIN BERNARD
    权利人:PFIZER
    摘要:The present invention relates to a method of making novel dipeptidyl peptidase-IV (“DPP-IV’) inhibitor compounds useful for treating, inter alia, diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, metabolic syndrome (Syndrome X or insulin resistance syndrome), hyperglycemia, impaired glucose tolerance, glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.

    专利号:US-2004002609-A1
    优先权日:2002-06-04
    标题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds

    专利号:US-2004242898-A1
    优先权日:2002-06-04
    标 题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds

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    合成参考文献


    摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 284.
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