CAS: 33948-22-0; 5H-Dibenzo[b,F]Azepine-5-Carbonyl Chloride

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甲基硝基苯置于盐酸,N-溴代丁二酰亚胺(Nbs),氢气,Sodium Amide体系中,用 甲苯 作为反应溶剂,化学反应生成 亚氨基芪甲酰氯
参考文献:Balaure,Paul Catalin; Costea,Ion; Iordache,Florin,Revue Roumaine De Chimie,2009,Vol. 54,# 11-12,P. 935-942
标题:Balaure,Paul Catalin; Costea,Ion; Iordache,Florin,Revue Roumaine De Chimie,2009,Vol. 54,# 11-12,P. 935-942

专利信息

专利号:US-2004152897-A1
优先权日:2002-09-13
标 题 :Synthesis of indolizines
发明人：SUN LIJUN; KOYA KEIZO; XIA ZHI-QIANG; PRZEWLOKA TERESA; ZHANG SHIJIE; ONO MITSUNORI
权利人:SYNTA PHARMACEUTICALS CORP
摘要:Disclosed are methods of preparing substituted indolizines represented by the following formula: n n n comprising reacting a substrate represented by the following formula: n n n with either the cyclization reagent of the following formula: n n n or, a reagent prepared by reacting the compound represented the formula below with an alkylating agent: n n n The variables in the above formulas are defined herein.

专利号:US-5110923-A
优先权日:1990-07-18
标题 :Method for preparing 5-chlorocarbonyl-5h-dibenz(b,f)azepine
发明人：PALITSCH PETER; CZERNOTZKY KLAUS; RICHTER ERHARD; KREHER BERNDT; KLUMP WILIFRIED; MUELLER RAINER
权利人:DRESDEN ARZNEIMITTEL
摘要:The invention is directed to a process for the synthesis of 5-chlorocarbonyl-5H-dibenz[b,f]azepine, which is the precursor for the industrial scale synthesis of 5-carbamoyl-5H-dibenz[b,f]azepine. The latter substance is used as pharmaceutical compound. In the process phosgene is passed into a suspension of iminostilbene in an inert solvent at 20° C.-60° C. until the iminostilbene reacted to form an almost equimolar mixture of 5-chlorocarbonyl-5H-dibenz[b,f]azepine and iminostilbene hydrochloride, and then iminostilbene is released from the iminostilbene hydrochloride by the addition of an aqueous base. The iminostilbene so released is also made available for a complete phosgenation while an acidic reaction environment is maintained. After the iminostilbene reacted completely, the reaction mixture is heated slowly to 20° C.-90° C. with stirring and is detoxified by the hydrochloric acid that is formed.

专利号:CN-112624971-A
优先权日:2019-09-24
标 题:Synthesis of 8-position Aryl-Substituted Quinoline Nitrogen Oxides by a Rhodium-Catalyzed Carbon-Hydrogen Bond Activation Reaction