CAS: 33898-90-7; 3-Oxo-3-(2-Thienyl)Propionitrile

该化合物是一种多用途的有机化合物,与β-氯硝基苯基集团相联系,具有硫苯基,这种结构使其成为合成有机化学中有价值的中间体,特别是在准备三环化合物和药品方面.氯酮和硝基苯的功能都允许多种反应,包括凝聚,循环和核循环添加反应.它的硫苯环增强了电子特性,使其在材料科学和农用化学应用中有用.该化合物在标准条件下具有良好的稳定性,便利了处理和储存.其合成效用和结构特点使它成为开发新化学实体的研究人员的首选选择.

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物理性质

MSDS等安全信息

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ECHA物质C&L通报

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CAS号3437-95-4 2-碘噻吩 | CAS号18293-53-3 (三甲硅基)乙腈 | CAS号201230-82-2 carbon monoxide | CAS号636-72-6 2-噻吩甲醇 | CAS号75-05-8 乙腈 | CAS号301164-69-2 1-(2-噻吩基羰基)-1H-苯并三唑 | CAS号326-91-0 2-噻吩甲酰三氟丙酮 | CAS号19158-51-1 4-甲苯磺酰氰 | CAS号5380-42-7 2-噻吩甲酸甲酯 | CAS号1003-31-2 2-氰基噻吩 | CAS号21582-46-7 (2-氨基噻吩-3-基)(噻吩... | CAS号29462-24-6 (2-amino-4,5,6,... | CAS号52200-22-3 3-(二甲基氨基)-2-(2-... | CAS号118430-78-7 1-甲基-3-(噻吩-2-基)... | CAS号116539-57-2 R-(+)-3-甲氨基-1-(... | CAS号914644-30-7 N-[3-(thiophene... | CAS号62455-60-1 3,3-双(甲基硫代)-2-(...

合成工艺路线路线简述

    📜3-Oxo-3-Thiophen-2-Yl-Dithiopropionic Acid Methyl Ester置于sodium Azide体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 2.0H,以74%的收率获得2-噻吩基乙酰腈
    参考文献:1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应:通过分子内n-O键形成区域选择性合成3,5-双(杂)芳基异恶唑
    标题:1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应:通过分子内n-O键形成区域选择性合成3,5-双(杂)芳基异恶唑
    摘要:据报道,在ibx催化剂存在下,一种有效的新的3,5-双(杂)芳基异恶唑合成涉及1,3-双(杂)芳基单硫-1,3-二酮与叠氮化钠的反应.该反应在室温下以高收率进行,适用于多种底物,包括5-甲基-3-芳基异恶唑的合成,5-甲基-3-芳基异恶唑是几种抗β-内酰胺酶的抗生素中存在的关键亚基.已经提出了形成异恶唑的可能机理.还通过使相应的1-(杂)芳基-1-(甲硫基)-4-(杂)亚芳基-丁-1-烯-反应而合成了一些5-苯乙烯基/芳基丁二烯基-3-(杂)芳基异恶唑.在较高温度下与叠氮化钠共3个.β-酮二硫酯与叠氮化钠的反应显示出可提供高产率的β-酮腈.
    Doi:10.1021/acs.Joc.0C02216

    海关参考信息

    专利信息


    专利号:US-8188113-B2
    优先权日:2006-09-14
    标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
    发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
    权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
    摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

    专利号:US-7034154-B2
    优先权日:1999-08-10
    标 题:Synthesis of substituted pyrazolopyrimidines
    发明人：GROSS RAYMOND S; WILCOXEN KEITH M; OGLESBY RICHARD CHRISTOPHER
    权利人:NEUROCRINE BIOSCIENCES INC
    摘要:Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

    专利号:US-6472528-B1
    优先权日:1999-08-10
    标题 :Synthesis of substituted pyrazolopyrimidines

    专利号:US-2003004346-A1
    优先权日:1999-08-10
    标题:Synthesis of substituted pyrazolopyrimidines

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    主要参考文献

    参考标题:Efficient Approach To Amide Bond Formation With Nitriles And Peroxides: One-Pot Access To Boronated β-Ketoamides
    作者:Babasaheb Sopan Gore,Gopal Chandru Senadi,Amol Milind Garkhedkar,Jeh-Jeng Wang |发布日期:2017.9.4
    摘要:An Efficient, Mild And Practical Approach For The Synthesis Of Amides From Nitriles And Peroxides Is Reported In The Presence Of Boron Trifluoride Ethereate. In This Protocol, We Utilized Peroxides As C1 Synthons For The Amidation Reaction. Also, We Successfully Prepared Boron‐containing β‐ketoamides In A One‐pot Assembly From β‐ketonitriles. A Variety Of Functional Groups Were Tolerated In Moderate

    合成参考文献


    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 219.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 143.
    摘要:Vilhelmsen, M. H., Science of Synthesis Knowledge Updates, (2014) 2, 363.
    摘要:Tong, M. L.; Kunz, K.; Jaschinski, M.; Holzschneider, K.; Celik, I. E.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2020) 2, 270.
    摘要:Wu, X.; Xiao, J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 282.
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