CAS: 32829-58-6; Gigantin

专利信息

专利号:WO-2017053290-A1
优先权日:2015-09-23
标题:Ribotoxin molecules derived from sarcin and other related fungal ribotoxins
发明人：GEHLSEN KURT R; JONES TIMOTHY DAVID; CARR FRANCIS JOSEPH; HEARN ARRON
权利人:RES CORP TECH INC
摘要:The present application relates to modified T cell epitopes derived from fungal ribotoxins, including α-sarcin, clavin, gigantin, mitogillin, and restrictocin, as well as modified ribotoxin molecules comprising the modified epitopes. The modified ribotoxin molecules inhibit protein synthesis, like the wild type ribotoxins, but exhibit reduced immunogenicity as compared to the corresponding wild type ribotoxin. Another aspect relates to a fusion protein which comprises a modified ribotoxin fused or conjugated or otherwise linked to a targeting molecule that is effective for binding a target of interest. Another aspect relates to the use of the modified ribotoxin or fusion protein for treating or managing a disease or condition.