CAS: 24974-73-0; (3-Chlorophenyl)Methanesulfonyl Chloride

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CAS号620-20-2 3-氯氯苄 | CAS号133067-71-7 S-(3-chloro)ben... | CAS号89782-88-7 1-(3-氯苯基)甲烷磺酰胺

📜间氯氯苄置于盐酸体系中,用 乙醇,水,乙腈 用作溶剂,化学反应 1.0H,反应生成(3-氯苯基)甲基磺酰氯
参考文献:通过n-氯代琥珀酰亚胺氯磺化反应从s-烷基异硫脲盐中方便,环保地合成磺酰氯
标题:通过n-氯代琥珀酰亚胺氯磺化反应从s-烷基异硫脲盐中方便,环保地合成磺酰氯
摘要:摘要 已经开发了一种方便,实用和环境友好的合成磺酰氯的方法.由s-烷基异硫脲盐以中等至优异的收率合成结构多样的磺酰氯,其可以容易地由易于获得的烷基卤化物或甲磺酸酯和廉价的硫脲通过n-氯代琥珀酰亚胺氯磺化制备.在大规模合成中,可以将来自"废水"的副产物琥珀酰亚胺与次氯酸钠(漂白剂)方便地转化为起始试剂n-氯琥珀酰亚胺,以使该方法具有可持续性. 已经开发了一种方便,实用和环境友好的合成磺酰氯的方法.由s-烷基异硫脲盐以中等至优异的收率合成结构多样的磺酰氯,其可以容易地由易于获得的烷基卤化物或甲磺酸酯和廉价的硫脲通过n-氯代琥珀酰亚胺氯磺化制备.在大规模合成中,可以将来自"废水"的副产物琥珀酰亚胺与次氯酸钠(漂白剂)方便地转化为起始试剂n-氯琥珀酰亚胺,以使该方法具有可持续性.
Doi:10.1055/s-0033-1338743

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.