专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-10787576-B2 优先权日:2015-04-30 标 题 :Method for the preparation of a coating comprising oligomeric alkynes 发明人:FRAUENRATH HOLGER; SCHRETTL STEPHEN; SCHULTE BJOERN; LETERRIER YVES 权利人:ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL TTO 摘要:The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N) x -(L) m -(Câ•?C) n -(L′) o -(N′) y —R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C) n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C 1 -C 25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis ofthe monomers according to the invention.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:CN-101365674-A 优先权日:2005-07-21 标题:Modulators of interleukin-1 and tumor necrosis factor alpha, synthesis of the modulators and methods of using the modulators
专利号:US-6583315-B2 优先权日:2000-12-23 标 题:Process for preparing ethanebis(alkylphosphinic) acids 发明人:SICKEN MARTIN; WEFERLING NORBERT; SCHMITZ HANS-PETER 权利人:CLARIANT GMBH 摘要:The invention relates to a process for preparing ethanebis(alkylphosphinic) acids by n a) reacting elemental yellow phosphorus with alkyl halides in the presence of alkali metal hydroxide or of alkaline earth metal hydroxide to give a mixture whose main constituents are the alkali metal salts and/or alkaline earth metal salts of alkylphosphonous, phosphorous, and hypophosphorous acid, n b) liberating alkylphosphonous, phosphorous, and hypophosphorous acid by adding mineral acids, and also at the same time precipitating the alkali metal ions and, respectively, alkaline earth metal ions in the form of their salt of the mineral acids, and then n c) esterifying the alkylphosphonous acid from the mixture of the alkylphosphonous, phosphorous, and hypophosphorous acid, n d) isolating the ester of alkylphosphonous acid from the mixture and hydrolyzing the same to give alkylphosphonous acid, and n e) preparing, from the alkylphosphonous acid, the corresponding ethanebis(alkylphosphinic) acid of the general formula (I) where R 1 and R 2 may be identical or different and are hydrogen, a carboxy group, a carboxylic acid derivative, an unsubstituted or substituted alkyl group having from 1 to 10 carbon atoms, phenyl, benzyl, or alkyl-substituted aromatics, and R 3 and R 4 are identical or different and are an unsubstituted or substituted alkyl group having from 2 to 20 carbon atoms, by free-radical-initiated reaction with alkynes, and also to the use of the ethanebis(alkylphosphinic) acids prepared by this process as starting material for preparing flame retardants and precursors for the synthesis of other phosphorus-containing compounds.
专利号:WO-9632368-A1 优先权日:1995-04-11 标题:One-pot synthesis of ring-brominated benzoate compounds