CAS: 207671-50-9; 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One Xhydrate

专利信息

专利号:US-2023069886-A1
优先权日:2020-01-10
标 题 :Aromatic sulphonamides derivatives that inhibits pdi a3, their synthesis and use
发明人：CHLOPICKI STEFAN; KALVINS IVARS; PRZYBOROWSKI KAMIL; STOJAK MARTA; ANDRIANOV VICTOR; DOMRACEVA ILONA; KANEPE-LAPSA IVETA; ZELENCOVA DIANA; WIETRZYK JOANNA; TURLEJ ELIZA; STACHOWICZ MARTYNA; JAROSZ JOANNA; MILCZAREK MAGDALENA; KRAMKOWSKI KAROL
权利人:UNIV JAGIELLONSKI
摘要:The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.