CAS: 170564-98-4; (R)-1-Phenyl-3-Propanolamine

相似化合物

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上下游产品

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3-氨基-3-苯基-1-丙醇置于sodium Hydroxide,Phosphate Buffer,Penicillin G Acylase Immobilized On Epoxy-Resin体系中,用 乙醇,水 用作溶剂,化学反应 5.0H,反应生成(R)-3-氨基-3-苯基丙醇
参考文献:Preparation Of Enantiomerically Pure (R)-And (S)-3-Amino-3-Phenyl-1-Propanol Via Resolution With Immobilized Penicillin G Acylase
标题:Preparation Of Enantiomerically Pure (R)-And (S)-3-Amino-3-Phenyl-1-Propanol Via Resolution With Immobilized Penicillin G Acylase
摘要:Ethyl 2,4-Dioxo-4-Phenylbutyrate,Obtained By Condensation Of Acetophenone With Diethyl Oxalate,Was Converted To 3-Oxo-3-Phenyl-1-Propanol In 90% Yield By Reaction With Baker'S Yeast. Reductive Amination With Sodium Cyanoborohydride In The Presence Of Ammonium Acetate Gave The Racemic 3-Amino-3-Phenyl-1-Propanol In 65% Yield. Enzymatic Resolution Of The Corresponding N-Phenylacetyl Derivative With Penicillin G Acylase,Immobilized On An Epoxy Resin Gave (S)-Amide And (R)-Amino Alcohol In High Enantiomeric Purity (Ee > 99%) And > 45% Yields For Each Enantiomer. (C) 2006 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2005.12.022

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2003114679-A1
优先权日:2001-09-12
标 题:Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

专利号:US-2005080267-A1
优先权日:2001-09-12
标 题:Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

专利号:ZA-200400750-B
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings.

专利号:CN-105837657-B
优先权日:2016-04-21
标 题:Chemical Total Synthesis of Peptides Without Amino Acids

专利号:EP-1487795-A4
优先权日:2001-09-12
标题 :SYNTHESIS OF ENANTIOMERICALLY PURE AMINO-SUBSTITUTED FUSIONNATED BICYCLIC CORES