CAS: 16849-88-0; 2-((Dimethylamino)Methylene)Malononitrile

该化合物是有机化合物,其独特结构包括二甲基氨基化合物和两个半甲基(硝基)功能组,其特点是一种无色的黄液或固态,视其特定形式和纯度而定,以其无色性为蓝黄色液体或固质,以反应性为著称,特别是由于有硝基子组的存在,可参与各种化学反应,包括核生殖添加和聚合过程;二甲基氮基组有助于其基本性和作为核素的潜力;该化合物经常用于有机合成,并可作为生产药品或农用化学品的一个中间体;安全考虑十分重要,因为它可能是有毒的,应在受控制的实验室环境中以适当的防范方式加以处理.

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2407-68-3 28976-80-9 35520-41-3

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上下游产品

N,N-dimethylvinylamine tricyanoethene N,N-dimethyl-formamide dimethyl acetalN,N-dimethyl-formamide dimethyl acetal aminomethylene-malononitrile 2-cyano-3-dimethylamino-thioacrylamide 2-((benzylamino)methylene)malononitrile 7-amino-1-methylpyrazolo[1,5-a]pyrimidine-6-carbonitrile 2-methyl-4-amino-5-cyanopyrimidine

合成工艺路线路线简述

    📜(2E)-3-(二甲基氨基)-2-甲酰基丙烯腈置于1,2-二氯乙烷体系中,用 0-Acetylhydroxylamine Hydrochloride 用作溶剂,化学反应生成(二甲基氨亚甲基)丙二腈
    参考文献:Process For Producing Dialkyl Aminoacrylonitrile
    标题:Process For Producing Dialkyl Aminoacrylonitrile
    摘要:通过在存在脱氢催化剂的情况下,用氢受体处理二甲基氨基丙腈来生产二烷基氨基丙烯腈的工艺.因此生产的二烷基氨基丙烯腈被转化为氨基亚甲基丙二腈,这是硫胺素的已知中间体.

    海关参考信息

    专利信息


    专利号:US-3853946-A
    优先权日:1971-11-11
    标题 :Process for the preparation of aminomethylene malononitrile
    发明人:LEIMGRUBER W; WEIGELE M
    权利人:HOFFMANN LA ROCHE
    摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

    专利号:US-3900511-A
    优先权日:1973-03-05
    标 题 :Process for the preparation of aminomethylene malononitrile
    发明人:LEIMGRUBER WILLY; WEIGELE MANFRED
    权利人:HOFFMANN LA ROCHE
    摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

    专利号:US-3742015-A
    优先权日:1968-04-09
    标题:Process for the preparation of aminomethylene malononitrile
    发明人:LEIMGRUBER W; WEIGELE M
    权利人:HOFFMANN LA ROCHE
    摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacrylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

    专利号:US-4180663-A
    优先权日:1977-08-01
    标 题:Methine dye synthesis
    发明人:FRISHBERG MARK D
    权利人:EASTMAN KODAK CO
    摘要:A process for the preparation of a disperse methine dye containing at least one dicyanomethylidene group comprising the steps of (A) preparing an anhydrous solution of an aldehyde formed by contacting an aromatic amine, 1,2,3,4-tetrahydroquinoline or benzomorpholine compound capable of undergoing the Vilsmeier-Haack reaction with POCl3 and a N,N-di-alkylformamide wherein the alkyl moiety is 1-4 carbon atoms; (B) subsequently adding to said solution at least one equivalent of cyanoacetamide based on the equivalents of aldehyde formed in (A), thereby forming a reaction mixture of aldehyde and in situ generated malononitrile; and (C) adjusting the pH of the solution to a point sufficient for the condensation of the aldehyde and in situ generated malononitrile to occur thereby producing a disperse methine dye.

    专利号:US-3655716-A
    优先权日:1968-04-09
    标题:Cyano containing hydrazones and methyl sulfate salts thereof
    发明人:LEIMGRUBER WILLY; WEIGELE MANFRED
    权利人:HOFFMANN LA ROCHE
    摘要:THIS INVENTION IS DIRECTED TO A PROCESS FOR THE PREPARATION OF AMINOMETHYLENE AMALONONITRILE FROM DIALKYL AMINOACRYLONITRILE INCLUDING INTERMEDIATES THEREIN. AMINOMETHYLENE MALONONITRILE IS A KNOWN COMPOUND WHICH IS A VALUABLE INTERMEDIATE IN THE SYNTHESIS OF THIAMINE.

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    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#09600
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