CAS: 16732-64-2; 4-Bromo-1H-Indole-2-Carboxylic Acid

相似化合物

103858-52-2 167479-13-2 955978-74-2

上下游产品

4-溴吲哚-2-甲酸乙酯 Ethyl 4-Bromo-1H-Indole-2-Carboxylate 103858-52-2

2-溴-6-硝基甲苯置于盐酸,Potassium Ethoxide,氨,Iron(II) Sulfate体系中,用 乙醇 用作溶剂,化学反应生成4-溴吲哚-2-羧酸
参考文献:Indoline Analogs Of Idazoxan: Potent .Alpha.2-Antagonists And .Alpha.1-Agonists
标题:Indoline Analogs Of Idazoxan: Potent .Alpha.2-Antagonists And .Alpha.1-Agonists
摘要:The Synthesis And Alpha-Adrenergic Activity Of A Series Of Substituted 2-Imidazolinylindolines Are Described. Substitution In The Indoline Ring Generated Compounds With A Spectrum Of Adrenoceptor Antagonist/agonist Profiles That Proved Sensitive To Both The Nature And Position Of The Substituent. Many Of The Derivatives Possess Greater Presynaptic Antagonist Potency Than The Corresponding Benzodioxan 1,Dihydrobenzofuran 2,And Indan 3 Analogues; However,This Alpha 2-Antagonism Is Often Accompanied By Alpha 1-Agonist Activity. It Was Not Possible To Separate Alpha 2-Antagonist From Alpha 1-Agonist Properties In This Series. Compounds Of Most Interest Proved To Be The N-Ethyl 6,5-Chloro-N-Methyl 18,And 5-Chloro-N-Ethyl 23 Derivatives,All Being Potent Alpha 2-Antagonists And Alpha 1-Agonists. Substitution At The 4-And 7-Position Of The Indoline Ring Generally Gave Compounds With Nonselective Agonist Properties.
Doi:10.1021/jm00400A009

专利信息

专利号:US-9738661-B2
优先权日:2006-10-27
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; HARPER STEVEN; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.