CAS: 1617-17-0; 2-Chloropropionitrile

相似化合物

29617-66-1 7474-05-7 27816-36-0

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CAS号27816-36-0 2-氯丙酰胺 | CAS号78-97-7 乳腈 | CAS号107-13-1 丙烯腈 | CAS号76-02-8 三氯乙酰氯 | CAS号107-12-0 丙腈 | CAS号19481-82-4 2-溴丙腈 | CAS号75-44-5 光气 | CAS号74-90-8 氢氰酸 | CAS号75-07-0 乙醛 | CAS号7782-50-5 氯气 | CAS号27816-36-0 2-氯丙酰胺 | CAS号598-78-7 2-氯丙酸 | CAS号50712-63-5 2-(4-硝基苯基)丙腈 | CAS号18151-58-1 2-trimethylsily... | CAS号250651-54-8 2-(1-chloroethy... | CAS号1823-91-2 2-苯丙腈 | CAS号107-13-1 丙烯腈 | CAS号74-90-8 氢氰酸 | CAS号3696-36-4 1-异喹啉硼酸 | CAS号78232-00-5 methylmalononit...

📜乳腈置于三聚氯氰体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成2-氯丙腈
参考文献:镍催化的杂芳基碘化物和 α-氯腈之间的不对称还原交叉偶联
标题:镍催化的杂芳基碘化物和 α-氯腈之间的不对称还原交叉偶联
摘要:已开发出 Ni 催化的杂芳基碘化物和 α-氯腈的不对称还原交叉偶联.该方法从简单的有机卤化物构建块中提供对映体富集的 α,α-二取代腈.该反应耐受多种杂环偶联物,包括吡啶,嘧啶,喹啉,噻吩和哌啶.该反应在温和的室温条件下进行,不需要预生成有机金属亲核试剂.
Doi:10.1021/jacs.5B06466

专利信息

专利号:US-11459303-B2
优先权日:2019-06-21
标题 :Process for the synthesis of lofexidine
发明人：DONNOLA MONICA; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of lofexidine of formula (I) and the hydrochloride salt thereof (II), from ethyl 2-(2,6-dichlorophenoxy)propionate (III) and ethylenediamine in the presence of tetravalent titanium alkoxides, preferably titanium isopropoxide, in an apolar solvent such as toluene. A further object of the present invention is a process for the preparation of the intermediate ethyl 2-(2,6-dichlorophenoxy)propionate (III) from 2,6-dichlorophenol and ethyl 2-chloropropionate in the presence of a polar aprotic solvent and an alkali or alkaline earth carbonate salt, preferably potassium carbonate. Both processes are more cost-effective and more easily industrially scalable than the known procedures, thus enabling the active ingredient to be obtained with high yields at a limited cost.

专利号:US-6162882-A
优先权日:1996-07-10
标 题:Preparation of novel homo- and copolymers using atom transfer radical polymerization
发明人：MATYJASZEWSKI KRZYSZTOF; COCA SIMION; GAYNOR SCOTT G; NAKAGAWA YOSHIKI; JO SEONG MU
权利人:UNIV CARNEGIE MELLON
摘要:The present invention is directed to a process of atom (or group) transfer radical polymerization for the synthesis of novel homopolymer or a block or graft copolymer, optionally containing at least one polar group, with well defined molecular architecture and narrow polydipersity index, in the presence of an initiating system comprising (i) an initiator having a radically transferrable atom or group, (ii) a transition metal compound, and (iii) a ligand, the present invention is also directed to the synthesis of a macromolecule having at least two halogen groups which can be used as a macroinitiator component (i) to subsequently form a block or graft copolymer by an atom or group transfer radical polymerization process; the present invention is also directed to a process of atom or group transfer radical polymerization for the synthesis of a branched or hyperbranched polymer; in addition, the present invention is directed to a process of atom or group transfer radical polymerization for the synthesis of a macroinitiator which can subsequently be used to produce a block or graft copolymer.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-12053529-B2
优先权日:2018-08-01
标题:Amino-reactive positively charged ATRP initiators that maintain their positive charge during synthesis of biomacro-initiators
发明人：RUSSELL ALAN J; MURATA HIRONOBU
权利人:UNIV CARNEGIE MELLON
摘要:Provided herein are materials and methods that include utilizing atom transfer radical polymerization (ATRP) initiator molecules that maintain a positive charge during biomacro-initiator synthesis.

专利号:US-5856501-A
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives
发明人：MALCOLM ARCELIO J; WU TSE-CHONG
权利人:ALBEMARLE CORP
摘要:N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

专利号:US-5281725-A
优先权日:1991-10-07
标 题:Derivatives of 2,2-dihalogenobenzo[1,3]dioxoles substituted in the 4-position, processes for their preparation and their use
发明人：ANDRES PETER; MARHOLD ALBRECHT
权利人:BAYER AG
摘要:New 2,2-dihalogeno-benzo[1,3]dioxoles substituted in the 4-position, of the general formula (I) ##STR1## in which R represents fluorine, chlorine, bromine or nitro and n Hal represents chlorine or fluorine, and their use as starting substances for the synthesis of highly active compounds, for example in the field of plant protection and pharmaceuticals. n The compounds of the formula (I) can be prepared by analogous processes, for example by chlorination from corresponding benzo[1,3]dioxoles substituted in the 4-position, and these substances according to the invention can be further reacted with hydrogen fluoride to give substances to which the invention likewise relates.