CAS: 143060-31-5; Boc-D-Ala(3,3-Diphenyl)-Oh

相似化合物

149597-92-2 149597-91-1 201484-50-6

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate (R)-β,β-diphenyl-α-alanine hydr°Chloride tert-butyl [(2R)-3-hydroxy-1,1-diphenylpropan-2-yl]carbamate benzyl (R)-2-(N-tert-butoxycarbonylamino)-3,3-diphenylpropanoate (R)-β,β-diphenyl-α-alanine hydr°Chloride (S)-1-((R)-2-tert-Butoxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid methyl ester (R)-2-tert-butoxycarbonylamino-3,3-dicyclohexyl-propionic acid

N-[(R)-α-Methylbenzyl]Aziridine-2(S)-Diphenylmethanol置于palladium Dihydroxide 氢氧化钾,Jones Reagent,氢气体系中,用 甲酸,乙醇,二氯甲烷,丙酮 用作溶剂,20.0 °C,689.47 Kpa 条件下,反应 20.0H,反应生成Boc-D-3,3-二苯基丙氨酸
参考文献:Chang,Jae-Won; Ha,Hyun-Joon; Park,Chan Sun,Heterocycles,2002,Vol. 57,# 6,P. 1143-1148
标题:Chang,Jae-Won; Ha,Hyun-Joon; Park,Chan Sun,Heterocycles,2002,Vol. 57,# 6,P. 1143-1148

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.