CAS: 1093860-48-0; Methyl 6-Chloropyridazine-4-Carboxylate

相似化合物

1256794-24-7 286946-24-5 34127-22-5

上下游产品

diazomethane 6-chloropyridazine-4-carboxylic acid6-chloropyridazine-4-carboxylic acid

📜3-氯-5-甲酸哒嗪,Trimethylsilyldiazomethane 以 甲醇,正己烷,二氯甲烷 用作溶剂,化学反应 2.0H,以42%的收率获得6-氯哒嗪-4-羧酸甲酯
参考文献: Pyrazolopyrimidine As Malt-1 Inhibitors[fr] Pyrazolopyrimidine Utilisés En Tant Qu'Inhibiteurs De Malt-1
标题: Pyrazolopyrimidine As Malt-1 Inhibitors[fr] Pyrazolopyrimidine Utilisés En Tant Qu'Inhibiteurs De Malt-1
摘要:该发明提供了一种化合物,其化学式为(i):在此,系列(x),(y)和(z)中的r1,R2和r3如规范中定义,它们是malt1酶的有效抑制剂,并且在免疫肿瘤学方法中对癌症的治疗中特别适用,尤其是膀胱癌,结肠癌,肝细胞癌或小细胞或非小细胞肺癌.

专利信息

专利号:WO-2024159284-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:WO-2024159288-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting amides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting amides. More specifically, the present invention relates to amides comprising formula (I): (Ia) (Ib), in which the substituents R1 to R27 are selected independently of the groups defined in the description, as well as to processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.