CAS: 932710-63-9; 4-(Di-Tert-Butylphosphino)-N,N-Dimethylaniline

上下游产品

di-tert-butylphosphine 4-bromo-N,N-dimethylaniline N,N-dimethyl-anilineN,N-dimethyl-aniline di(tert-butyl)chlorophosphine[Pd(Amphos)(cinnamyl)Cl] [Pd(4-(di-tert-butylphosphino)-N,N-dimethylaniline)(trifluoroacetate)(κ2-N,C-C6H4CH2NMe2)] 9-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-o-[4-(1,3-oxazol-2-yl)benzyl]-β-D-ribofuranosyl}-6-[2-(trimethylsilyl)ethoxy]-9H-purine bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

4-氯-N,N-二甲基苯胺置于碘,Magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.67H,反应生成 [(4-(N,N-二甲氨基)苯基]二叔丁基膦
参考文献:一种二氯二叔丁基-4-二甲基氨基苯基膦钯的制备方法
标题:一种二氯二叔丁基-4-二甲基氨基苯基膦钯的制备方法
摘要:本发明公开的二氯二叔丁基‑4‑二甲基氨基苯基膦钯的制备方法,包括以下步骤:步骤1,使用原料n,N‑二甲基对卤苯胺与镁屑制备格氏试剂;步骤2,取格氏试剂并降温,随后加入催化剂后反应,再滴加二叔丁基氯化磷,升温后反应即得到二叔丁基‑4‑二甲氨基苯基膦;步骤3,对二叔丁基‑4‑二甲氨基苯基膦纯化处理;步骤4,取双(乙腈)二氯化钯与纯化后的二叔丁基‑4‑二甲氨基苯基膦进行络合反应,即得到目标产物.本发明的制备方法通过对二叔丁基‑4‑二甲氨基苯基膦进行纯化处理,用高纯度的二叔丁基‑4‑二甲氨基苯基膦与双(乙腈)二氯化钯反应,大大降低了贵金属钯的收率损失,使制备成本大幅降低,有很好的实用价值.

专利信息

专利号:US-11180508-B2
优先权日:2017-12-05
标 题:Chemical process for the synthesis of herbicidal pyrazolidinedione compounds
发明人：MORRIS JAMES ALAN; SHAFIR ALEXANDR; GONU MALLIKHARJUNA; BILAL IFFAT; SALE DAVID ALEXANDER
权利人:SYNGENTA PARTICIPATIONS AG
摘要:The present invention relates to a novel process for the synthesis of herbicidal pyrazolidinedione compounds. In particular, a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined herein. The present invention further relates to novel intermediate compounds utilized in said process, and methods for preparing said intermediate compounds.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:WO-2025137396-A1
优先权日:2023-12-20
标题 :Synthesis of bromodomain inhibitors
发明人：PLAMONDON LOUIS; PATEL JATIN; WANG YI; SUN CUIXIANG
权利人:CONSTELLATION PHARMACEUTICALS INC
摘要:Provided herein are processes which are useful for the preparation of small molecule bromodomain inhibitors.

专利号:US-2024309013-A1
优先权日:2021-11-19
标 题:SYNTHESIS OF 2'-(7,7-dimethyl-1'H,7H-spiro[furo[3,4-b]pyridine-5,4'-piperidin]-1'-yl)-1,3-dihydro-4'H-spiro[indene-2,5'-[1,3]oxazol]-4'-one
发明人：ADAM JEAN-MICHEL; BACHMANN STEPHAN; BIGLER RAPHAEL; DOTT PASCAL; FANTASIA SERENA MARIA; GROSSE-SENDER KATJA; JAMES PHILIPPE; SPURR PAUL; THUN JUERGEN; TONAZZI SANDRO; TOSATTI PAOLO
权利人:HOFFMANN LA ROCHE
摘要:The invention provides crystalline forms of 2′-(7,7-dimethyl-1′H,7H-spiro[furo[3,4-b]pyridine-5,4′-piperidin]-1′-yl)-1,3-dihydro-4′H-spiro[indene-2,5′-[1,3]oxazol]-4′-one, and a process for converting Form A to Form B for use in medicaments for treatment of anxiety, depression, irritability, impaired social interactions and psychomotor coordination, and other indications. The invention further provides processes to manufacture 2′-(7,7-dimethyl-1′H,7H-spiro[furo[3,4-b]pyridine-5,4′-piperidin]-1′-yl)-1,3-dihydro-4′H-spiro[indene-2,5′-[1,3]oxazol]-4′-one. Also disclosed are compounds useful as intermediates in the methods of the invention.

专利号:WO-2021249877-A1
优先权日:2020-06-08
标 题 :Intermediates and processes for the preparation of tolvaptan and its derivatives
发明人：VIGO DANIELE; CAPUTO FRANCESCO; COLOMBO FRANCESCO
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:The present invention relates to new intermediates for the synthesis of Tolvaptan and of its derivatives and a process for its preparation involving said intermediates.

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.