CAS: 91608-15-0; Tris(2,4,6-Trimethoxyphenyl)Phosphine

该化合物是一种受到阻碍的三级磷酸酯,其特点是其电子富含和多体芳香替代成分.甲氧基混合物增加了极地有机溶剂的溶性,同时提供了稳定的氧化作用.这一混合物在金属催化的过渡反应中特别有用,如交叉和氢化,其成份可促进高度选择性和再活性.其坚固的结构还最大限度地减少不理想的侧面反应,使之适合要求合成应用.该化合物在环境条件下的稳定性进一步简化了处理和储存.研究人员认为它对于精细化学合成和有机金属化学的可预测性能很有价值.

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CAS号34425-71-3 1-lithium-2,4,6... | CAS号621-23-8 1,3,5-三甲氧基苯 | CAS号101-02-0 亚磷酸三苯酯

合成工艺路线路线简述

  • 621-23-8 = 91608-15-0
    反应条件:1.1 Reagents: Butyllithium1.2 Reagents: Triphenylphosphine Solvents: Diethyl Ether1.3 Reagents: Water Solvents: Water
    标题:Mercury(Ii) Halide Complexes Of Tertiary Phosphines. Part Xvii. Complexes Of The Very Basic And Sterically Demanding Ligand,Tris(2,4,6-Trimethoxyphenyl)Phosphine (Tmpp) Of Stoichiometry (Tmpp)X(Hgx2)Y (X = Cl,Br,I; X = 1,2; Y = 1: X = 2,Y = 3: X = I; X = 1,Y = 2). Crystal Structures Of The Monomeric 1:1 Complexes (Tmpp)Hgx2 (X = Br,I) And (Tmpp)(Hgi2)2
    作者:Bell,Norman A.; Coles,Simon J.; Constable,Christopher P.; Hursthouse,Michael B.; Light,Mark E.; Et Al
    参考文献:Polyhedron 日期:2002 卷标:21(18) 页码:1845-1855]

    = 91608-15-0
    反应条件:1.1 Reagents: Trimethylphosphine Solvents: Toluene,Cyclopentyl Methyl Ether; 12 H,100 °C
    标题:A Clean And Simple Method For Deprotection Of Phosphines From Borane Complexes
    作者:Demchuk,Oleg M.; Jasinski,Radomir; Strzelecka,Dorota; Dziuba,Kamil; Kula,Karolina; Et Al
    参考文献:Pure And Applied Chemistry 日期:2018 卷标:90(1) 页码:49-62]

    34425-71-3 = 91608-15-0
    反应条件:1.1 Solvents: Diethyl Ether
    标题:A Highly Basic And Nucleophilic Triphenylphosphine,Tris(2,4,6-Trimethoxyphenyl)Phosphine,And Related Compounds
    作者:Wada,Masanori; Higashizaki,Shogo; Tsuboi,Aki
    参考文献:Journal Of Chemical Research 日期:1985 卷标:(2) 页码:38-9
📜1-锂-2,4,6-三甲氧基苯置于亚磷酸三苯酯体系中,用 乙醚 作为反应溶剂,以70%的收率获得产物三(2,4,6-三甲氧基苯基)磷
参考文献:高碱性三苯膦[2,4,6-(meo)3 C 6 H 2] 3 P
标题:高碱性三苯膦[2,4,6-(meo)3 C 6 H 2] 3 P
摘要:发现三(2,4,6-三甲氧基苯基)膦是高度碱性的(p K A,11.2).
DOI:10.1039/c39840000482

海关参考信息

专利信息


专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-2022288005-A1
优先权日:2019-07-26
标题:Synthesis of pro-resolving analogs and compositions therefor
发明人:VAN DYKE THOMAS E; SERHAN CHARLES N
权利人:NOCENDRA INC
摘要:This disclosure relates to methods of synthesizing certain lipoxin analogs (e.g., lipoxin mimetics, etc.) and pharmaceutical compositions comprising these pro-resolving compounds. Methods of administering the lipoxin mimetics (e.g., lipoxin A4 mimetics, lipoxin B4 mimetics, etc.) to patients in need thereof are also provided.

专利号:US-2010056392-A1
优先权日:2005-06-15
标题:Microstructure and microdomain microarrays, methods of making same and uses thereof
发明人:GREVING MATTHEW; WOODBURY NEAL; NORTHEN TRENT R
权利人:GREVING MATTHEW; WOODBURY NEAL; NORTHEN TRENT R
摘要:Disclosed are methods for direct characterization of microdomains and/or three-dimensional microstructure arrays bearing high densities of reactive sites using Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometery (MALDI-MS) and other analytical techniques. The high site density of the arrays can provide sufficient sample of each array element and/or materials bound to each element to obtain directly using common analytical techniques such as MALDI-MS. Spatially directed synthesis of heteropolymers is done through the use of pliotolabile, electrically labile, and chemically labile protecting group(s).

专利号:EP-0444889-A1
优先权日:1990-02-26
标 题:Novel synthesis of carbapenem intermediates
发明人:RANO THOMAS A; GREENLEE MARK L; DININNO FRANK P
权利人:MERCK & CO INC
摘要:Carbapenems having the formula: are prepared by a novel reaction of a readily accessible carbapenem intermediate and an organostannane. The reaction, which is mediated by a palladium compound and, optionally, a phosphine ligand, proceeds at remarkably mild temperatures in reproducibly good yields.

专利号:US-12275752-B2
优先权日:2019-06-13
标 题 :Class of phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application
发明人:MA SHENGMING; LIU QI; XU HAIBO
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention discloses a phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application. The ligand has the axial chirality of a biaryl skeleton and the central chirality of a chiral amine. The chiral ligand is synthesized from commercially available raw materials through a simple five-step reaction, and the resulting diastereomer can be separated by simple column chromatography or recrystallization. The chiral phosphine nitrogen ligand synthesized by the present invention can catalyze the asymmetric three-component coupling reaction of terminal alkynes, aldehydes and amines, and realize the efficient preparation of chiral propargyl amines with high optical activity.

专利号:US-2025002508-A1
优先权日:2020-05-05
标题 :Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
发明人:HECKER SCOTT J; BOYER SERGE HENRI; BIO MATTHEW M; FANG YUANQING; GONZALES DE CASTRO ANGELA; LEFORT LAURENT; ZHU ZUOLIN; LINDER THOMAS
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

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合成参考文献


摘要:Mase, N., Science of Synthesis Knowledge Updates, (2013) 3, 319.
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