CAS: 83133-17-9; 4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone

该化合物是一种特定的裂变衍生物,其特征是4'和5位置的氢氧化物组和3',5',6 和7位置的甲氧代用品,这种结构配置有助于其潜在的生物活动,其独特的混合体是氢氧和甲氧基组,可能使其具有特定的药理特性,或成为化学研究中有价值的合成前体.

英文名称4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone
中文名称4',5-二羟基-3',5',6,7-四甲氧基黄酮
IUPAC名称5-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
其它别名5-Hydroxy-2-(4-Hydroxy-3,5-Dimethoxyphenyl)-6,7-Dimethoxy-4H-Chromen-4-One; 4H-1-Benzopyran-4-One, 5-Hydroxy-2-(4-Hydroxy-3,5-Dimethoxyphenyl)-6,7-Dimethoxy-; 5-Dihydroxy-3'; 7-Tetramethoxyflavone; 5,4'-Dihydroxy-6,7,3',5'-Tetramethoxyflavone; 4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone; 4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone
CAS编号83133-17-9
分子式:C19H18O8分子量:374.35
产品CID: 1820466
产品分类天然产物 → 黄酮类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: XEHLDSAKZSXOFK-UHFFFAOYSA-N
InChI=1S/C19H18O8/c1-23-13-5-9(6-14(24-2)17(13)21)11-7-10(20)16-12(27-11)8-15(25-3)19(26-4)18(16)22/h5-8,21-22H,1-4H3
计算化学: 氢键受体数8.0氢键供体数2.0可旋转键数5.0

物理性质

沸点610.4±55.0 °C at 760 mmHg
闪点220.6±25.0 °C
密度1.4±0.1 g/cm3
PSA:107.59
LogP:1.26
折射率1.613
蒸汽压0.0±1.8 mmHg at 25°C
溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
外观形态黄色粉末
储存条件2-8°C

MSDS等安全信息

危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
危险品标志Xi
安全声明H303+H313+H333

上下游产品

CAS号22248-14-2 2,3,4-三甲氧基-6-羟基苯乙酮 | CAS号14588-60-4 4-(苄氧基)-3,5-二甲氧基苯甲酸 | CAS号14588-61-5 3,5-dimethoxy-4...

合成工艺路线路线简述

合成目标产物 4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone 主要起始原料 4H-1-Benzopyran-4-One, 2-(4-Hydroxy-3,5-Dimethoxyphenyl)-5,6,7-Trimethoxy-
93124-90-4 = 83133-17-9
反应条件:1.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

= 83133-17-9
反应条件:1.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C2.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

642-71-7 = 83133-17-9
反应条件:1.1 Reagents: Sodium Acetate; 110 °C1.2 Reagents: Acetic Acid,Boron Trifluoride Etherate; Heated2.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Heated2.2 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C3.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C4.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

74-95-3 + 121-33-5 = 83133-17-9
反应条件:1.1 Reagents: Sodium Bicarbonate,Potassium Iodide,Iodine (I2-) Solvents: Water; Rt1.2 Reagents: Sodium Hydroxide,Copper Sulfate Solvents: Water; Reflux1.3 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 110 °C2.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Heated2.2 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C3.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C4.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

= 83133-17-9
反应条件:1.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C2.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

134-96-3 + 22248-14-2 = 83133-17-9
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Heated1.2 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C2.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C3.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

5780-07-4 + 22248-14-2 = 83133-17-9
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Heated1.2 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C2.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C3.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075]

86-81-7 = 83133-17-9
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane; Rt1.2 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Rt2.1 Reagents: Sodium Acetate; 110 °C2.2 Reagents: Acetic Acid,Boron Trifluoride Etherate; Heated3.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Heated3.2 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C4.1 Reagents: Iodine (I2-) Solvents: Dimethyl Sulfoxide; 110 °C5.1 Reagents: Aluminum Chloride Solvents: Acetonitrile; 80 °C
标题:Synthesis And Anti-Proliferative Activities Of 5,6,7-Trimethoxyflavones And Their Derivatives
作者:Su,Liang; Et Al
参考文献:Natural Product Research 日期:2022 卷标:36(16) 页码:4070-4075

📜3,4,5-三甲氧基苯酚置于aluminum (Iii) Chloride,硫酸,Sodium Acetate,Potassium Hydroxide体系中,用水,二甲基亚砜,乙腈作为反应溶剂,化学反应 76.0H,反应生成 4',5-二羟基-3',5',6,7-四甲氧基黄酮
参考文献:5,6,7-三甲氧基黄酮及其衍生物的合成及抗增殖活性
标题:5,6,7-三甲氧基黄酮及其衍生物的合成及抗增殖活性
摘要:摘要一系列5,6,7-三甲氧基黄酮1A-1G及其衍生物2A-2G,3A-3D,4和5,包括天然产物5,6,7-三甲氧基-4'-羟基黄酮(1A),5,6,7,3',4'-Pentamethoxyflavone (Sinensetin,1 B),5,6,7-Trimethoxy-3',4'-Methyl Enedioxy Flavone (1C),5,6,7,3'-Tetramethoxy-4,5'-亚甲二氧基黄酮 (1E),5,6,7,3',4',5'-六甲氧基黄酮 (1 G),5-Hydroxy-3,4,2',3',4'-五甲氧基硫醇-Cone (2 B),5,4'-Dihydroxy-6,7-Dimethoxy Flavone (Cirsimaritin,3A) 和 5-Hydroxy-6,7,3',4'-Tetramethoxyflavone
DOI:10.1080/14786419.2021.1961136