乙基丙二酸二乙酯置于sodium Hydride,1-(N-Butyl)-2,4,6-Triphenylpyridinium Tetrafluoroborate体系中,化学反应生成 二乙基丙二酸二乙酯 参考文献:Alkylation Of Monosubstituted Malonate Anions With Pyridinium And Quinolinium Salts 标题:Alkylation Of Monosubstituted Malonate Anions With Pyridinium And Quinolinium Salts 摘要:单取代的丙二酸盐在室温下与1-(次烷基)喹啉盐反应反应生成烷基化产物.因此,可以在非常温和的条件下制备出受阻的双取代丙二酸酯. DOI:10.1055/s-1987-27938
专利号:EP-2070915-A1 优先权日:2007-12-03 标 题 :New process for the synthesis of moguisteine
专利号:CN-101268037-A 优先权日:2005-09-19 标题 :Asymmetric Synthesis of (S)-(+)-3-(Aminomethyl)-5-Methylhexanoic Acid
专利号:ES-2367466-T3 优先权日:2007-12-03 标 题:NEW PROCESS FOR THE SYNTHESIS OF MOGUISTEÃ?NA.
专利号:EP-2231627-A2 优先权日:2007-12-03 标题:New process for the synthesis of moguisteine
专利号:US-9433623-B2 优先权日:2012-09-14 标 题 :Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi 发明人:LEVINA ELIZABETH 权利人:LEVINA ELIZABETH 摘要:The invention relates to chemistry and pharmacology, in particular to synthetic biologically active substances of the pyrimidine series that have antimicrobial activity, and to the method of synthesis thereof. According to the invention there is provided a new substance with activity against gram positive bacteria, mycobacteria and fungi characterized in that it constitutes 5-(2-hydroxybenzylidene) derivatives of the pyrimidinone series with the general formula 1 where XI, X3 are selected from the group containing: H, halogen; N02; X2, X4 are selected from the group containing: H, halogen: Z is selected from the group containing: 0, NNH2, NOH, pei†iydropyrimidine-5-ytidene-2,4,6-trione, perhydropyrimidine-5-ylidene-2,4,6-trione, substituted at the nitrogen atom With alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K.
专利号:CN-105439862-A 优先权日:2015-12-24 标 题:Synthesis method of barbitone drug intermediate diethyl diethylmalonate