CAS: 7417-18-7; 2-(2-Methoxyphenyl)Ethanol

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2-(2-Methoxyphenyl)Oxirane置于tropylium Tetrafluoroborate,频那醇硼烷体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应 24.0H,以66%的收率获得产物1-(2-甲氧基苯基)乙醇
参考文献:Tropylium 促进的硼氢化反应:通过实验和计算研究的机理见解
标题:Tropylium 促进的硼氢化反应:通过实验和计算研究的机理见解
摘要:炔烃的硼氢化反应是合成有机硼化合物最强大的工具之一,有机硼化合物是交叉偶联化学的通用前体.这种类型的反应传统上是由过渡金属或主族催化剂介导的.在此,我们报告了一种使用通常称为有机氧化剂和路易斯酸的镨盐来促进炔烃的硼氢化反应的新方法.通过这种无金属协议,可以轻松访问范围广泛的乙烯基硼烷.烯烃和环氧化物的类似硼氢化反应也可以由相同的托鎓催化剂有效催化.实验研究和 Dft 计算表明,该反应遵循一种不常见的机制途径,这是由频哪醇硼烷与 Tropylium 离子的氢化物提取所触发的.接下来是一系列原位反离子活化的取代基交换以反应生成促进硼氢化反应的硼中间体.
DOI:10.1021/acs.Joc.1C01208

专利信息

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-5145865-A
优先权日:1989-04-19
标 题 :Phenylcarboxylic acid derivatives having hetero ring
发明人：FUJII SETSURO; FUJII ADMINISTRATOR BY SHINICH; TAKADA ADMINISTRATOR BY KAORUK; KAWAMURA HIROYUKI; WATANABE SHINICHI
权利人:OTSUKA PHARMA CO LTD
摘要:Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: ##STR1## wherein R 1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R 1 ) k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R 2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.