📜2-氨基-4-甲基-5-硝基吡啶置于palladium 10% On Activated Carbon,氢气体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以3.2 G的收率获得产物4-甲基-2,5-二氨基吡啶 参考文献:Inhibitors Of Hepatitis C Virus Replication 标题:Inhibitors Of Hepatitis C Virus Replication 摘要:本发明涉及一种具有式(i)的化合物,该化合物可用作丙型肝炎病毒(hcv)ns5A抑制剂,以及该类化合物的合成,以及利用该类化合物抑制hcv Ns5A活性,用于治疗或预防hcv感染,以及在基于细胞的系统中抑制hcv病毒复制和/或病毒产生.
专利号:US-2022356182-A1 优先权日:2009-03-27 标题 :Inhibitors of hepatitis c virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-11053243-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9090661-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
参考标题: Inhibitors Of Hepatitis C Virus Replication Inhibiteurs De La Réplication Du Virus De L'Hépatite C 摘要:The Present Invention Relates To Compounds Of Formula (I) That Are Useful As Hepatitis C Virus (Hcv) Ns5A Inhibitors, The Synthesis Of Such Compounds, And The Use Of Such Compounds For Inhibiting Hcv Ns5A Activity, For Treating Or Preventing Hcv Infections And For Inhibiting Hcv Viral Replication And/or Viral Production In A Cell-Based System.