CAS: 627-12-3; Propyl Carbamate

该化合物是一种有机化合物,被归类为氨酸甲酯,其特征是,氨酸甲酯功能组中有一个附着的丙基化合物组,该组由碳基(C=O)与氮原子(N)结合,也与烷基或亚里尔组相关联.该化合物一般看起来无色,可粉黄液体或固体,视其纯度和形态而定.丙皮尔碳酸酯以其毒性低闻名,并经常用于各种用途,包括溶剂,药品合成和有机化学的中间.该化合物在水中表现出中等溶性,在有机溶剂中更溶解.该化合物在正常条件下稳定,但在接触强酸或基体时可能分解.该化合物的特性使其在研究和工业应用中有用,尽管由于潜在刺激效应,应采取安全防范措施妥善处理它.

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合成工艺路线路线简述

    📜氯甲酸丙酯置于氨,水体系中,化学反应生成 丙基碳酸酯
    参考文献:Roemer,Chemische Berichte,1873,Vol. 6,P. 1102
    标题:Roemer,Chemische Berichte,1873,Vol. 6,P. 1102

    海关参考信息

    专利信息


    专利号:US-10253153-B2
    优先权日:2015-04-24
    标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
    发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
    权利人:NITTO DENKO CORP
    摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

    专利号:US-2006287520-A1
    优先权日:2005-05-16
    标 题 :Synthesis of salinosporamide A and analogues thereof
    发明人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
    权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
    摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

    专利号:US-8445713-B2
    优先权日:2007-10-22
    标 题 :Catalyst for the synthesis of organic carbonates, process for preparing the same and application thereof
    发明人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING
    权利人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING; BAYER MATERIALSCIENCE AG
    摘要:The present invention relates to a catalyst for the synthesis of organic carbonates, the preparation of the catalyst and the application of this catalyst in the synthesis of organic carbonates from reacting urea and hydroxyl group containing compounds. The catalyst provided in this invention is a calcinate of hydrous salt containing rare earth element at a moderate calcining temperature.

    专利号:WO-2012047907-A9
    优先权日:2010-10-04
    标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
    发明人:MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
    权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
    摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

    专利号:US-10487048-B2
    优先权日:2015-03-13
    标 题:Configuration and its use in process for synthesis of alkyl carbamates from alkyl alcohol and urea in a tubular reactor
    发明人:RANADE VIVEK VINAYAK; KELKAR ASHUTOSH ANANT; RANE VILAS HARI; KINAGE ANIL KISAN; MOTE DHANANJAY RAVINDRA; SHINGOTE SAVITA KIRAN; ROY LALITA SANJIB
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention discloses an improved catalyst free process for synthesis of alkyl carbamates in an integrated system comprising a tubular reactor and a striper. The process comprises reacting urea and an alcohol in said tubular reactor under autogeneous pressure; wherein said process provides >90% selectivity towards alkyl carbamate. The mixture of urea and alcohol is N fed to the tubular reactor at a particular feed rate. The tubular reactor is heated externally under autogeneous pressure to carry out a synthesis reaction producing alkyl carbamate and ammonia. The ammonia is removed from the tubular reactor by the striper. The tubular reactor and the stripper are arranged in series to reduce the equilibrium limitations of the reaction and drive the reaction in forward direction.

    专利号:US-2009221568-A1
    优先权日:2005-11-04
    标题:Synthesis of Inhibitors of FtsZ
    发明人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
    权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
    摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 141.
    摘要:Australian Journal of Experimental Biology and Medical Science., 45(507), 1967 []
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
    摘要:Mill T et al; Environmental Fate and Exposure Studies Development of a PC-SAR for Hydrolysis: Esters, Alkyl Halides and Epoxides. EPA Contract No. 68-02-4254. Menlo Park, CA: SRI International (1987)
    摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/Q_schafer832.pdf
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