CAS: 60323-96-8; 2-Chloro-5-Methyl-4-Nitropyridine 1-Oxide

该化合物是一种环环形结构为环形环状的环形杂交有机化合物,代之以氯原子,甲基组和硝基化合物,以及N-氧化功能组,该化合物一般是固体,因其生物活动而有可能应用于制药和农用化学,已知其可能用于制药和农业化学,硝基亚化合物的存在有助于其回作用,而N-氧则影响其电子特性和溶解性.重要的是要谨慎地处理该化合物,因为它可能表现出毒性或环境危害.该化合物的合成通常涉及特定化学反应,将各种子体引入对丙烯环,其特性的描述可以使用NMR光谱,质量光谱测定和红外光谱分析等技术来证实其结构和纯度.

结构式图片

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14432-16-7 1074-98-2 14248-66-9

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上下游产品

CAS号20173-49-3 2-氯-5-甲基吡啶-N-氧化物 | CAS号18368-64-4 2-氯-5-甲基吡啶 | CAS号220899-66-1 N-ethyl-1-hydro... | CAS号79055-62-2 2-氯-4-氨基-5-甲基吡啶

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于硫酸,硝酸体系中,化学反应生成 2-氯-5-甲基-4-硝基吡啶-N-氧化物
    参考文献:Preparation And Reactions Of 2-Nitropyridine-1-Oxides
    标题:Preparation And Reactions Of 2-Nitropyridine-1-Oxides
    摘要:
    DOI:10.1021/ja01570A070

    海关参考信息

    专利信息


    专利号:US-12358877-B2
    优先权日:2019-03-05
    标题:Synthesis of 4-amino-5-methyl-1H-pyridin-2(1H)-on (intermediate compound for the synthesis of the MR antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine
    发明人：PLATZEK JOHANNES; LOVIS KAI
    权利人:BAYER AG; Bayer Pharma AG
    摘要:The present invention relates to a novel and improved method for preparing 4-amino-5-methylpyridone of the formula (I)which is an intermediate in the preparation of the MR antagonist finerenone.

    专利号:WO-2020178175-A1
    优先权日:2019-03-05
    标题:Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine

    专利号:EP-3935045-B1
    优先权日:2019-03-05
    标题 :Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-one (intermediate in the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-pyridinamine via the intermediate 2-chloro-5-methyl-4-pyridineamine

    专利号:CO-2021011553-A2
    优先权日:2019-03-05
    标 题:Synthesis of 4-amino-5-methyl-1h-pyridin-2 (1h) -on (intermediate compound for the synthesis of the antagonist mr finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1 -oxide using the intermediate 2-chloro-5-methyl-4-pyridinamine

    专利号:MX-2021010612-A
    优先权日:2019-03-05
    标题 :Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine.

    专利号:CL-2021002316-A1
    优先权日:2019-03-05
    标题:Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the antagonist mr finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1- oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine

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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2022)
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