CAS: 5962-41-4; 2-Phosphonopropanoic Acid

相似化合物

4378-40-9 4408-78-0 40962-37-6

上下游产品

methyl 2-(diethoxyphosphoryl)propanoate ethyl 2-diethoxyphosphorylpropionate

📜三乙基2-膦酰基丙酯 以 盐酸 作为反应溶剂,化学反应 3.0H,以to Yield 2-Phosphonopropionic Acid (Quantitative)的收率获得产物2-膦酰基丙酸
参考文献:Phosphonoacyl Prolines And Related Compounds
标题:Phosphonoacyl Prolines And Related Compounds
摘要:新的磷酸酰脯氨酸和相关化合物的一般结构式为##str1## 其中r.Sub.1和r.Sub.2分别为氢,低碳基,低烯基,未取代或取代的苯基-低碳基或金属离子;r.Sub.3为氢或低碳基;r.Sub.4为氢,低碳基,苯基-低碳基或金属离子;n为0或1.这些化合物可用作降压剂.

专利信息

专利号:EP-0468457-B1
优先权日:1990-07-24
标题 :Novel substituted piperidines and their use as inhibitors of cholesterol synthesis
发明人：MCCARTHY JAMES R; BARNEY CHARLOTTE L; WANNAMAKER MARION W
权利人:MERRELL DOW PHARMA
摘要:The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.

专利号:US-4539410-A
优先权日:1982-09-30
标题:N-Substituted-2-(1-imidazolyl)indoles
发明人：RENFROE HARRIS B
权利人:CIBA GEIGY CORP
摘要:Various 1-carboxylic acid substituted-2-(1-imidazolyl)indoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, methods of treatment utilizing such compounds and intermediates for their synthesis are included.

专利号:US-6140515-A
优先权日:1997-09-24
标题 :Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of COX-2
发明人：CHEN CHENG Y; TAN LUSHI; LARSEN ROBERT D
权利人:MERCK & CO INC
摘要:Described is a process of preparing 3-aryl, 4-aryloxy furan-5-ones which are useful as inhibitors of cyclooxygenase-2 (COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a trisubstituted styrene derivative preparation via Horner-Wadsworth-Emmons reaction and subsequent one pot trifluoromethylation of the allylic alcohol; preparation of the alpha -hydroxyl ketone using Sharpless asymmetric dihydroxylation and Swern oxidation; the esterification of the alpha -hydroxyl ketone with the phenoxy acetic acid; and the Dieckman condensation of the resulting ester.

专利号:US-7973109-B2
优先权日:2007-03-29
标 题 :Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution
发明人：OGATA SHIN-ICHI; FUKUSHIMA YOSHIAKI; KAWASUMI MASAYA
权利人:TOYOTA CHUO KENKYUSHO KK
摘要:A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above.

专利号:US-7420070-B2
优先权日:2000-12-28
标 题:Process for preparing optically active 2,3-dihydrobenzofuran compounds
发明人：AOKI ISAO; ADACHI MARI; TAWADA HIROYUKI; YAMASHITA MAKOTO; SERA MISAYO
权利人:TAKODA PHARMACEUTICAL COMPANY
摘要:A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: n n[wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

专利号:US-2012164231-A1
优先权日:2009-08-25
标题 :Synthesis Of Oxygen Carrying, Turbulence Resistant, High Density Submicron Particulates