CAS: 50-66-8; 6-(Methylthio)Purine

该化合物是纯净衍生物,其特点是在纯核心结构的6个位置上存在一个甲基硫基组,该化合物是有机合成和制药研究的多用途中间体,特别是在开发核素类仿和酶抑制剂方面,其反应性甲基硫基会促进进一步功能化,使其对药用化学的改造具有价值.纯基脚架在结构上具有重要意义,因为它在生物系统中发挥作用,它与涉及核糖核酸代谢和受体相互作用的研究有关.该化合物通常在受控制的条件下处理,因为其敏感性,确保合成应用的稳定.

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相似化合物

1198-47-6 33312-93-5 5417-84-5

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上下游产品

CAS号87-42-3 6-氯嘌呤 | CAS号5188-07-8 甲硫醇钠 | CAS号50-44-2 6-巯基嘌呤 | CAS号342-69-8 6-(甲硫基)-9-β-D-呋... | CAS号109403-64-7 N-(2-Furanylmet... | CAS号342-69-8 6-(甲硫基)-9-β-D-呋... | CAS号14671-26-2 N-pentyl-7H-pur... | CAS号1928-89-8 9H-Purine,6-(1-... | CAS号19769-32-5 6-methylsulfony... | CAS号21268-11-1 1-diethylamino-... | CAS号19769-31-4 6-methylsulfiny... | CAS号2846-96-0 4-(1H-嘌呤-6-基)吗啉 | CAS号23526-11-6 Inosine,2'-deox... | CAS号2846-81-3 9H-Purine,9-(2-...

合成工艺路线路线简述

    📜6-甲硫基-9-(四氢吡喃-2-基)嘌呤置于盐酸体系中,用 甲醇 作为反应溶剂,以68 %的收率获得产物6-甲巯基嘌呤
    参考文献:Mitsunobu 反应对 6-硫嘌呤衍生物的烷基化
    标题:Mitsunobu 反应对 6-硫嘌呤衍生物的烷基化
    摘要:摘要 据报道,通过 Mitsunobu 反应,硫嘌呤衍生物与醇的烷基化反应收率适中.将该方法应用于多种硫嘌呤和硫嘌呤核苷衍生物的合成.
    DOI:10.1080/15257770.2022.2163501

    海关参考信息

    专利信息


    专利号:US-6608196-B2
    优先权日:2001-05-03
    标题 :Process for solid supported synthesis of pyruvate-derived compounds
    发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
    权利人:GALILEO PHARMACEUTICALS INC
    摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

    专利号:US-7141434-B2
    优先权日:2002-07-16
    标 题 :Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an adenosine kinase
    发明人：MASUDA ESTEBAN; KINSELLA TODD M; WARNER JUSTIN E; KINOSHITA TAISEI; BENNETT MARK K; ANDERSON DAVID C
    权利人:RIGEL PHARMACEUTICALS INC
    摘要:The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

    专利号:US-3150124-A
    优先权日:1962-03-16
    标题:Synthesis of kinetin glycosides
    发明人：GEORGE SVARNAS; HERMAN RUTNER
    权利人:GEORGE SVARNAS; HERMAN RUTNER

    专利号:EP-1578931-A4
    优先权日:2002-07-16
    标 题:METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE THE SYNTHESIS OF IL-4 RECEPTOR-MEDIATED IGE USING ADENOSINE KINASE

    专利号:US-2008003620-A1
    优先权日:2002-07-16
    标题 :Methods of identifying compounds that modulate il-4 receptor-mediated ige synthesis utilizing an adenosine kinase

    专利号:US-2007054862-A1
    优先权日:2002-07-16
    标题 :Methods of Identifying Compounds that Modulate IL-4 Receptor-Mediated IgE Synthesis Utilizing an Adenosine Kinase

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    合成参考文献


    摘要:Liang, Y.; Wen, Z.; Cabrera, M.; Howlader, A. H.; Wnuk, S. F., Science of Synthesis Knowledge Updates, (2020) 1, 278.
    摘要:Liang, Y.; Wen, Z.; Cabrera, M.; Howlader, A. H.; Wnuk, S. F., Science of Synthesis Knowledge Updates, (2020) 1, 281.
    摘要:Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 624.
    摘要:Progress in Medical Chemistry., 7(69), 1970 []
    摘要:A. Albert. J. Chem. Soc., C 1969, 2379.
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