CAS: 34805-21-5; Boc-Met(O)-Oh

该化合物是氨基酸甲基硫磷的衍生物,其特点是存在一种三丁基氧基碳酸(Boc)保护基(Boc)保护组和一个硫氧化物功能组.Boc组通常用于peptide合成以保护氨基组,允许其他功能场有选择的反应.硫氧化物表明,甲硫磷中的硫磺原子已经氧化,可影响化合物的再活性和生物特性.这种化合物通常用于有机合成和丙二烯化学,特别是用于制作改良的聚苯乙烯或作为生物活性分子合成的中间体.其溶剂和稳定性可能因所使用的条件而不同,因此在处理和应用过程中必须考虑到这些因素.

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3226-65-1 62697-73-8 76265-70-8

上下游产品

N-tert-butoxycarbonyl-L-methionine2B°C-Met(O)-Asp(OBzl)-Phe-NH2 112H140Cl2N14O22S2C112H140Cl2N14O22S2 L-methionine gastrin-5

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    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:EP-0193910-A2
    优先权日:1985-03-06
    标题:Synthesis of a derivative of GRF and intermediate peptides

    专利号:US-4507230-A
    优先权日:1982-05-12
    标 题 :Peptide synthesis reagents and method of use
    发明人:TAM JAMES P; HEATH JR WILLIAM F; MERRIFIELD ROBERT B
    权利人:RESEARCH CORP
    摘要:A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF and a base for a time and under conditions effective to produce the release; wherein the amounts of HF and base in the mixture are adjusted so that said release occurs substantially by an SN2 mechanism.

    专利号:CN-106928313-B
    优先权日:2015-12-31
    标题 :Synthesis method of C-terminal modified peptide

    专利号:WO-2009000950-A1
    优先权日:2007-06-25
    标题:Method for the deblocking/deprotection of compounds obtained by solid phase synthesis

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    合成参考文献


    参考文献:10.1007/978-94-011-1470-7_80
    摘要:Mapelli C, Leftheris K. A rapid and efficient method of deoxygenation of sulfoxides applied to the reduction of methionine sulfoxide in peptide synthesis. 1993. In: Peptides 1992. : Springer Netherlands; 1993.
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