CAS: 2298-07-9; 1-Amino-4-Bromonaphthalene

相似化合物

4236-05-9 4766-33-0 136924-78-2

上下游产品

CAS号134-32-7 1-萘胺 | CAS号91394-66-0 1-乙酰氨基-4-溴萘 | CAS号103859-95-6 N-(4-溴-萘-1-基)-甲酰胺 | CAS号6330-51-4 N-(1-萘基)甲酰胺 | CAS号84-86-6 4-氨基-1-萘磺酸 | CAS号59557-93-6 1-溴-4-(二甲基氨基)萘 | CAS号91394-66-0 1-乙酰氨基-4-溴萘 | CAS号878671-94-4 4-环丙基-1-萘胺 | CAS号83-53-4 1,4-二溴萘 | CAS号134-32-7 1-萘胺 | CAS号2050-49-9 2,4-二溴-1-萘酚 | CAS号63279-58-3 1-溴-4-碘萘 | CAS号571-57-3 4-溴萘酚 | CAS号90-11-9 1-溴代萘 | CAS号30727-61-8 6-溴苯并[h]喹啉

1-萘胺置于n-溴酞亚胺体系中,用 乙醚 用作溶剂,化学反应 0.17H,以90%的收率获得4-溴-1-萘胺
参考文献:对溴芳族化合物的区域选择性合成
标题:对溴芳族化合物的区域选择性合成
摘要:取代苯环与 N-溴邻苯二甲酰亚胺在中性条件下反应得到相应的溴代衍生物,优先形成对溴代异构体而不是邻位异构体.简单的后处理程序最大限度地减少了产品的损失,并且收率非常好.
Doi:10.1002/jccs.200500082

专利信息

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-2003135046-A1
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:US-6492529-B1
优先权日:2000-01-18
标题 :Bis pyrazole-1H-pyrazole intermediates and their synthesis
发明人：KAPADIA SURESH R; SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. n Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: n wherein Alk, R x and R z are described herein.