专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-10077242-B2 优先权日:2014-12-01 标题 :Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction 发明人:GUPTON FRANK; MARTIN ALEX; SIAMAKI ALI; BELECKI KATHERINE 权利人:UNIV VIRGINIA COMMONWEALTH 摘要:Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.
专利号:US-9790207-B2 优先权日:2015-09-04 标题 :Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods 发明人:IVACHTCHENKO ALEXANDRE VASILIEVICH; MITKIN OLEG DMITRIEVICH 权利人:IVACHTCHENKO ALEXANDRE VASILIEVICH; IVASHCHENKO ANDREY ALEXANDROVICH; SAVCHUK NIKOLAY FILIPPOVICH; ALLA CHEM LLC 摘要:Compound represented by formula 1: n nor a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein:n nR1 is hydrogen, tert-butoxycarbonyl,n n nwhere R11 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy, and arrows (↠) indicate the position of substituents attachment;n nR2 is hydrogen, halogen, or C 1 -C 4 alkyl;n nR3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl;n n n n n n n n n n n n n where R41 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (↠) indicate the position of substituents attacment.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:JP-6856608-B2 优先权日:2014-02-24 标 题:Direct electrochemical synthesis of dope conductive polymer on metal alloy
专利号:WO-9925778-A1 优先权日:1997-11-14 标 题 :Synthesis and applications of intrinsically conductive polymer salts of polyphosphonic acids in anti-corrosion coatings 发明人:KINLEN PATRICK J; DING YIWEI; KONCKI KENNETH F 权利人:ZIPPERLING KESSLER & CO 摘要:A coating composition for protecting a corrodible metal suface from corrosion includes an intrinsically conductive salt of a polyphosphonic acid as well as a solvent and other optional components. The composition is used to form a protective coating on the surface of corrodible metals such as iron and steel. The coating passivates the metal surface and complexes the passivated metal, thus protecting the surface from rust and corrosion.
参考标题:The Rational Design And Synthesis Of Water-Soluble Thiourea Ligands For Recoverable Pd-Catalyzed Aerobic Aqueous Suzuki-Miyaura Reactions At Room Temperature 作者:Wei Chen,Xiao-Yan Lu,Bei-Hua Xu,Wei-Guo Yu,Zi-Niu Zhou,Ying Hu |发布日期:2018.4 摘要:Black Precipitate Reveal That Pd Nanoparticles Are Formed During The Reactions And Are Stabilized By The Carboxylic-Functionalized Thiourea Ligands. Eight Precatalysts Containing Carboxylic-Functionalized Thiourea Ligands Are Prepared And Their Activities And Recyclability Are Evaluated In Aerobic Aqueous Suzuki-Miyaura Reactions. A Bulky Monothiourea-Pd Complex, Functionalized With Four Carboxylic Groups
合成参考文献
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 249.