专利号:US-2014194584-A1 优先权日:2013-01-07 标题 :Process for the synthesis of w-Unsaturated nitrile-acid/ester in which two types of cross metathesis are alternated consecutively swing process 发明人:DUBOIS JEAN-LUC; COUTURIER JEAN-LUC 权利人:ARKEMA FRANCE 摘要:The invention relates to a process for the synthesis of a monounsaturated nitrile-ester (acid) by cross metathesis starting from an unsaturated compound I comprising at least one trivalent nitrile, acid or ester functional group, characterized in that it comprises a stage in which two types of cross metathesis are alternated consecutively:n a first type of cross metathesis cm1 with an acrylic compound II chosen from acrylonitrile, acrylic acid or an acrylic ester, one of the compounds I or II comprising a nitrile functional group and the other of these compounds II or I comprising an acid or ester functional group, and a second type of cross metathesis cm2 with a light C 2 to C 4 alkene compound III, preferably with ethylene. nn The invention also relates to a process for the synthesis of an α,ω-amino ester (acid) obtained by a process comprising a stage in which the two types of cross metathesis defined above are alternated consecutively, followed by a hydrogenation stage.
专利号:WO-2025105947-A1 优先权日:2023-11-15 标 题 :Synthesis of polyols and polyesters by chemical degradation of industrial rubbers and natural rubbers for application in new polymer materials 发明人:TREVIÑO QUINTANILLA CECILIA DANIELA; BURELO TORRES JOSÉ MANUEL 权利人:INST TECNOLOGICO ESTUDIOS SUPERIORES MONTERREY 摘要:The present invention relates to a process for synthesising and obtaining biobased hydroxyl-terminated telechelic oligomers, such as biobased hydroxyl-terminated polybutadiene, by means of a degradation reaction via metathesis of industrial rubbers and using fatty alcohols as chain transfer agents (CTA). In particular, the present invention relates to the synthesis and production of diols, polyols and polyesters based on a degradation reaction via metathesis between industrial rubbers or natural rubbers and essential oils, fatty acids, fatty alcohols and terpenes with R-OH and R-COO-R terminal groups, the chemical structure, molecular weight and properties of which can be controlled.
专利号:EP-2134675-B1 优先权日:2007-04-06 标题 :Method for the co-production of cyclic carbonates and amino acids 发明人:DUBOIS JEAN-LUC 权利人:ARKEMA FRANCE 摘要:The invention relates to a conjugated method for the production of ?-amino-alkanoic acids and polyol carbonates from a natural monounsaturated fatty acid, comprising the following zones: I) zone for methanolysis of a natural oil containing a triglyceride with at least one monounsaturated fatty acid, producing methanolate from the fatty acid and glycerol; II) zone for synthesis of the ?-amino-alkanoic acid, comprising the following steps, namely (a) transformation of the methanolate into a ?-unsaturated fatty ester, either by ethenolysis of the methanolate or pyrolysis of a methanolate including an OH, (b) hydrolysis of the ester formed, (c) hydrobromination of the ?-unsaturated acid obtained in step (b) and (d) amination with ammonia of the compound resulting from the hydrobromination in step (C); III) zone for synthesis of a polyol carbonate by reacting urea either directly on the glycerol or on a diol obtained by hydrogenation reduction of the glycerol, the reaction of the polyol with the urea producing ammonia; IV) zone for recovery of the ammonia produced in zone III as well as that produced in zone IId where the reaction is performed with excess ammonia, for use in the amination of step (d) of zone II.
专利号:EP-2137133-B1 优先权日:2007-04-06 标题 :Method for the co-production of non-cyclic carbonates and amino acids 发明人:DUBOIS JEAN-LUC 权利人:ARKEMA FRANCE 摘要:The invention relates to a conjugated method for the production of ?-amino-alkanoic acids and dialkylcarbonates having formula R1O-CO-OR1,in which R1 has between 1 and 4 carbon atoms, from an unsaturated fatty acid ester, comprising the following reaction zones: I) zone for synthesis of the ?-amino-alkanoic acid with transformation of the fatty acid ester into a ?-unsaturated fatty ester, either by ethenolysis or pyrolysis, followed by hydrolysis of the ester into acid with formation of alcohol R1OH which is recovered and sent to zone III, subsequent hydrobromination of the ?-unsaturated acid obtained, followed by amination with excess ammonia to form the ?-amino-alkanoic acid, the excess ammonia being recycled in zone IV; II) zone for synthesis of a dialkylcarbonate having formula R1O-CO-OR1 by reaction with urea of R1OH originating from zone I via zone III, the ammonia produced being sent to zone IV; III) zone for recovery and purification of alcohol R1OH; and IV) zone for recovery and purificaiton of the ammonia originating from zones I and II for use as a reagent for the amination of zone I.
专利号:US-4233128-A 优先权日:1978-05-05 标 题:Photosynthesis of mercaptans 发明人:OLLIVIER JEAN; SOULOUMIAC GUY; SUBERLUCQ JEANNINE 权利人:ELF AQUITAINE 摘要:Synthesis of mercaptans by the photochemical reaction of an olefin with hydrogen sulphide in the presence of an initiator constituted by benzophenone, thiobenzophenone or a mixture of the two, preferably accompanied by an organic compound of an element of Group VA of the Periodic Classification. These initiators can carry substituents on either or both of the two benzene rings. The light utilized can have a wavelength of 300 to 600 nm. The process allows various mercaptans to be obtained with good yields.
专利号:US-6368831-B1 优先权日:1998-06-29 标题 :Treatment of hyperproliferative disorders 发明人:MAURER BARRY J; REYNOLDS C PATRICK 权利人:LOS ANGELES CHILDRENS HOSPITAL 摘要:A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-generating retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) ceramide degredation inhibitor, such as compounds selected from the group consisting of (i) glucosylceramide synthesis inhibitors and/or 1-acylceramide synthesis inhibitors, (ii) sphingosine-1-phosphate synthesis inhibitors, and (iii) protein kinase C inhibitors. A preferred glucosyl ceramide synthesis inhibitor is 1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred sphingosine-1-phosphate synthesis inhibitor is D-erythro-N,N-dimethylsphingosine. A preferred protein kinase C inhibitor is L-threo-dihydrosphingosine.
[参考文献]: Cristina Cruz-Hernandez, Et Al. Direct Quantification Of Fatty Acids In Human Milk By Gas Chromatography. J Chromatogr A. 2013 Apr 5;1284:174-9. [参考文献]: Jana Orsavova, Et Al. Fatty Acids Composition Of Vegetable Oils And Its Contribution To Dietary Energy Intake And Dependence Of Cardiovascular Mortality On Dietary Intake Of Fatty Acids. Int J Mol Sci. 2015 Jun 5;16(6):12871-90.
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