CAS: 16844-71-6; (3S,4R,4As,6As,6As,6Br,8Ar,12Ar,14As,14Bs)-4,4A,6A,6B,8A,11,11,14A-Octamethyl-1,2,3,4,5,6,6A,7,8,9,10,12,12A,13,14,14B-Hexadecahydropicen-3-Ol

上下游产品

friedelin D:A-friedo-oleanane 3α-acetoxyfriedelan 3-oxo-D:A-friedo-oleanan-25-yl-acetatebenzoic acid-(friedelanyl-(3α)-ester) 3α-methoxyfriedelan (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3R,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-°Ctamethyl-d°Cosahydro-picen-3-yl ester (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3R,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-°Ctamethyl-d°Cosahydro-picen-3-yl ester

无羁萜置于sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,以1.4 Mg的收率获得表木栓醇
参考文献:来自青蒿的细胞毒性萜类化合物和类黄酮.
标题:来自青蒿的细胞毒性萜类化合物和类黄酮.
摘要:在几种人类肿瘤细胞系上体外测试了从青蒿中分离出的9种萜烯和类黄酮的细胞毒活性.这些化合物是青蒿素,脱氧青蒿素,青蒿酸,青蒿素-B,豆甾醇,Friedelin,Friedelan-3β-Ol,青蒿素和槲皮素6,7,3',4'-四甲基醚.首次从该植物中分离出腓特烈类三萜.青蒿素和槲皮素6,7,3',4'-四甲醚显示出对p-388,A-549,Ht-29,Mcf-7和kb肿瘤细胞的明显细胞毒性.
Doi:10.1055/s-2006-959408

专利信息

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-2012184724-A1
优先权日:2009-09-22
标 题 :Protected monomers and methods of deprotection for rna synthesis
发明人：SIERZCHALA AGNIESZKA B; SMART BRIAN PHILLIP; DELLINGER DOUGLAS J; DELLINGER GERALDINE; MYERSON JOEL; TIMAR ZOLTAN
权利人:SIERZCHALA AGNIESZKA B; SMART BRIAN PHILLIP; DELLINGER DOUGLAS J; DELLINGER GERALDINE; MYERSON JOEL; TIMAR ZOLTAN; AGILENT TECHNOLOGIES INC
摘要:A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more 2 H, 13 C, or 15 N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.

专利号:US-2024336916-A1
优先权日:2020-03-26
标 题:Synthesis of modified oligonucleotides with increased stability

专利号:US-8242258-B2
优先权日:2006-12-03
标题 :Protecting groups for RNA synthesis
发明人：DELLINGER DOUGLAS J; STELL BRIAN; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; STELL BRIAN; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.

专利号:EP-4223315-A2
优先权日:2014-05-01
标 题:Method for synthesis of reactive conjugate clusters