CAS: 1596-84-5; Daminozide

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CAS号108-30-5 丁二酸酐 | CAS号57-14-7 偏二甲肼 | CAS号110-15-6 琥珀酸； 丁二酸

丁二酸酐,偏二甲肼置于sodium Benzoate,苯甲醛体系中,用 乙腈 用作溶剂,化学反应 0.17H,以114 G的收率获得丁酰肼
参考文献:一种制备高纯度n-二甲胺基琥珀酰胺酸技术改进方法
标题:一种制备高纯度n-二甲胺基琥珀酰胺酸技术改进方法
摘要:一种高纯度n‑二甲胺基琥珀酰胺酸技术改进方法,N‑二甲胺基琥珀酰胺酸(比久)又称阿拉(Alar85),丁酰肼,是一种用途广泛的精细化工产品,多用于生长调节剂.本发明为了完成和克服肼类化合物不稳定性引起的副产物多等缺点,加入少量稳定剂和终止反应后加入一种相关杂消除剂处理后再进行按常规方法冷却结晶,离心分离,重结晶和真空干燥得到高纯度,不含肼类高毒性残留的高纯度>=99.9%n‑二甲胺基琥珀酰胺酸原料,控制和消除了杂质全部来源,实现了商业规模生产,降低成本,设备简单等优点.

专利信息

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:WO-2024107075-A1
优先权日:2022-11-14
标 题 :Hybrid compounds of sclareol and doxorubicin, their synthesis and application
发明人：PESIC MILICA; OPSENICA IGOR; KOSTIC ANA; TERZIC-JOVANOVIC NATASA
权利人:INSTITUTE FOR BIOLOGICAL RESEARCH SINISA STANKOVIC NATIONAL INSTITUTE OF THE REPUBLIC OF SERBIA UNIV
摘要:The invention represents new hybrid compounds of two natural products sclareol and doxorubicin in the form of their conjugates. These compounds are in the form of conjugates, where doxorubicin and sclareol are covalently linked by a linker in a 1:1 molar ratio. The hybrids have shown to possess anticancer properties and are effective in treating resistant cancer cells that have P-glycoprotein membrane transporter, responsible for resistance to doxorubicin. The hybrids have been tested on different types of cell lines, including human glioblastoma, non-small cell lung carcinoma, and colorectal carcinoma. Also, a method for their preparation and their use in medical products or pharmaceutical preparations has been determined. The results of the study include the cytotoxic activity of single, combined, and conjugated compounds in pairs of sensitive and resistant cancer cells, with and without P-glycoprotein expression. The selectivity towards cancer cells was determined by comparing with commercially available normal human lung fibroblast cells. The study also investigated the nanoparticle nature of hybrid compounds, their intracellular localization and toxicity in vivo.

专利号:US-8147805-B2
优先权日:2005-01-05
标题:Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
发明人：YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND
权利人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND; UNIV T EXAS SYSTEM BOARD OF REGENTS
摘要:Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X 1 —Y—X 2 , wherein Y comprises two or more carbohydrate residues covalently attached to one another, X 1 and X 2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X 1 and X 2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

专利号:US-7745001-B2
优先权日:2004-03-23
标题:Synthesis of nanoassemblies containing luminescent quantum dots and magnetic nanoparticles
发明人：ROSENZWEIG ZEEV; CHEN YONGFEN; WANG DESHENG
权利人:UNIV NEW ORLEANS RES AND TECHN
摘要:Negatively charged luminescent CdSe—ZnS quantum dots (QDs) were successfully incorporated into novel luminescent glyconanospheres averaging around 190 nm in diameter through electrostatic interactions with carboxymethyldextran (CM-dextran) and polylysine. The glyconanospheres preferably contain as well carboxyl-modified iron oxide nanocrystals. In addition to electrostatic attraction between the negatively charged dextran, the negatively charged CdSe—ZnS QDs (and negatively charged iron oxide nanocrystals, if present), and the positively charged polylysine, covalent amide bonds were introduced to cross link the QDs (and negatively charged iron oxide nanocrystals, if present) with the polysaccharide matrix to further stabilize the glyconanospheres. The dextran residues on the surface of the nanospheres show high affinity toward the glucose binding protein-Concanavalin A (Con A). As a result, these luminescent CdSe—ZnS QD incorporated glyconanospheres are a useful tool for studying carbohydrate-protein interactions that are critical steps in bacterial and viral infection.

专利号:US-6297194-B1
优先权日:1999-02-02
标 题 :Production of phosphonopyrazoles
发明人：MILLER PAULA C; CURTIS JANE M; MOLYNEAUX JOHN M; OWEN THOMAS J
权利人:MONSANTO TECHNOLOGY LLC
摘要:Pyrazole compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat (Triticum aesativum) and other crops.

专利号:US-2002107401-A1
优先权日:2000-02-02
标题:Production of phosphonopyrazoles
发明人：MILLER PAULA C; CURTIS JANE M; MOLYNEAUX JOHN M; OWEN THOMAS J
权利人:MONSNTO TECHNOLOGY LLC
摘要:Novel compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat ( Triticum aesativum ) and other crops.