CAS: 152941-69-0; 6-Bromopyrido[2,3-D]Pyrimidine-2,4-Diamine
该化合物是一种溴化的环环化合物,其特点是2个和4个位置的[2,3-d]pyrimidine核心,具有氨基替代成分.这一结构具有重要的再活性,使它成为制药和农用化学合成中有价值的中间体.溴原子在Suzuki或Buchwald-Hartwig等交叉反应中提高了它的效用,从而能够进一步实现功能化.它的二胺组提供了更多的衍生点,有利于开发有针对性的生物活性分子.该化合物的稳定性和定义明确的再活性特征使其适合于医药化学应用,特别是用于设计止动剂或其他治疗剂.高纯度和连续性性能是研究和工业使用的关键优势.
- 英文名称6-Bromopyrido[2,3-D]Pyrimidine-2,4-Diamine
- 中文名称6-溴吡啶[2,3-d]嘧啶-2,4-二胺
- IUPAC名称6-bromopyrido[2,3-d]pyrimidine-2,4-diamine
- 其它别名6-溴吡啶并[2,3-D]嘧啶-2,4-二胺; 2,4-Diamino-6-Bromopyridopyrimidine
- CAS编号152941-69-0
- MFCD编号:MFCD08706204
- 分子式:C7H6BrN5分子量:240.06
- 产品CID: 750742
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
1121633-45-1 882670-89-5 882670-90-8MSDS等安全信息
上下游产品
2,4,6-triaminopyrimidine 2-Bromo-malonaldehyde 4-amino-6-bromo-2-pivaloylamino-5-deazapteridine 2-pivaloylamino-6-bromo-4(3H)-pyrido[2,3-d]pyrimidinone d]pyrimidine-2,4-diamine6-(2-chloro-benzyl)-pyrido[2,3-d]pyrimidine-2,4-diamine N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamideN-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide N-[6-(3,5-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamideN-[6-(3,5-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide pyridopyrimidine2,4-diamino-6-2-(3',4'-dimethoxyphenyl)ethenylpyrido2,3-dpyrimidine合成工艺路线路线简述
- 合成目标产物 6-Bromopyrido[2,3-D]Pyrimidine-2,4-Diamine 主要起始原料 N-(6-Bromo-4-Hydroxypyrido[2,3-D]Pyrimidin-2-yl)Pivalamide(Wxc05947)
- (文献来源)合成步骤主要原料 N-(6-Bromo-4-Hydroxypyrido[2,3-D]Pyrimidin-2-yl)Pivalamide(Wxc05947)
📜6-Bromo-2-Pivaloylamino-4<1'-(1,2,4-Triazolyl)>-5-Deazapteridine置于ammonium Hydroxide体系中,用 1,4-二氧六环 用作溶剂,化学反应 120.5H,反应生成6-溴吡啶并[2,3-D]-2,4-二氨基嘧啶
参考文献:Taylor,Edward C.; Otiv,S. R.; Durucasu,Inci,Heterocycles,1993,Vol. 36,# 8,P. 1883-1895
标题:Taylor,Edward C.; Otiv,S. R.; Durucasu,Inci,Heterocycles,1993,Vol. 36,# 8,P. 1883-1895
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7256197-B2
优先权日:2001-10-12
标 题 :Methods for synthesis of diarylmethanes
发明人：ROSOWSKY ANDRE; CHEN HAN
权利人:DANA FARBER CANCER INST INC
摘要:The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.
专利号:US-2004267011-A1
优先权日:2001-10-12
标题:Methods for synthesis of diarylmethanes
专利号:WO-03031458-A1
优先权日:2001-10-12
标题 :Methods for synthesis of diarylmethanes
