CAS: 152628-03-0; 4-Methyl-2-Propyl-1H-Benzo[d]Imidazole-6-Carboxylic Acid

上下游产品

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5-硝基间二甲苯置于n-羟基邻苯二甲酰亚胺,硫酸,5%-Palladium/activated Carbon,氢气,氧气,硝酸,Cobalt(II) 2-Ethylhexanoate,溶剂黄146体系中,用 甲醇 用作溶剂,-10.0~125.0 °C,1.0 Mpa 条件下,反应 27.0H,反应生成2-正丙基-4-甲基-6-羧基苯并咪唑
参考文献:2-正丙基-4-甲基苯并咪唑-6-羧酸的合成方 法
标题:2-正丙基-4-甲基苯并咪唑-6-羧酸的合成方 法
摘要:本发明涉及一种2‑正丙基‑4‑甲基苯并咪唑‑6‑羧酸的合成方法.3,5‑二甲基硝基苯经硝酸/浓硫酸硝化反应,生成中间产物ⅱ 3,5‑二甲基‑1,2‑二硝基苯;中间产物ⅱ在乙醇溶液中,Pd/c催化氢化反应,得中间产物ⅲ 3,5‑二甲基‑1,2‑苯二胺;中间产物ⅲ在多聚磷酸溶液中,与正丁酸反应,得到中间产物ⅳ 2‑正丙基‑4,6‑二甲基苯并咪唑;中间产物ⅳ在醋酸溶液中,经钴盐空气液相氧化反应,得产物v 2‑正丙基‑4‑甲基苯并咪唑‑6‑羧酸.本发明操作简单,原料易得,所用溶剂均能回收套用,产品含量可达95%以上,收率高达73.2%,污染少,适合于工业化生产.

专利信息

专利号:WO-2010149360-A1
优先权日:2009-06-26
标题:Process for the preparation of benzimidazoles
发明人：HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; LONG JUN
权利人:LONZA AG; HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; LONG JUN
摘要:Substituted benzimidazoles of formula (I), wherein R 1 and R 2 independently are hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl and R 3 is cyano or carboxy, are prepared in a multistep synthesis starting from Î -acyl-4-halo- anilines of formula (II), wherein R 1 and R 2 are as defined above and X is chlorine or bromine.

专利号:WO-2010149359-A1
优先权日:2009-06-26
标 题 :Process and intermediates for the preparation of benzimidazolecarboxylic acids
发明人：HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; HE WEI RYAN
权利人:LONZA AG; HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; HE WEI RYAN
摘要:Substituted benzimidazolecarboxylic acids of formula (I), wherein R 1 and R 2 independently are hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, are prepared in a four-step synthesis starting from N -acyl-4-haloanilines of formula (II), wherein R 1 is as defined above, R 3 is C 1-4 alkyl and X is chlorine or bromine.

专利号:WO-2009116089-A2
优先权日:2008-03-14
标题:Novel intermediates and method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'- bi-1hbenzimidazol]-l-yl)methyl]-1,1-biphenyl]-2-carboxylic acid.

专利号:WO-2011113351-A1
优先权日:2010-03-18
标 题:[(4-methyl-2-propyl-n-methoxy-substituted phenylalkyl-1h-benzimidazol-6-formamide)-1-yl]-methyl biphenyl compounds and their preparation methods
发明人：ZHOU ZHIMING; ZHANG JUN; LI ZHIHUAI; WANG JINLIANG
权利人:BEIJING INST TECHNOLOGY; ZHOU ZHIMING; ZHANG JUN; LI ZHIHUAI; WANG JINLIANG
摘要:[(4-methyl-2-propyl-N-methoxy-substituted phenylalkyl-1H-benzimidazol-6- formamide)-1-yl]-methyl biphenyl compounds of the following formula I, preparation methods and uses thereof are disclosed. The said preparation methods adopt the following synthetic routes. The said compounds can be used in the manufacture of medicaments for treating cardiovascular and cerebrovascular diseases. The said compounds have good inhibition activities of angiotensin II AT1 receptors. The preparation method has the advantages of simple synthesis process and easy obtainment of raw materials and is beneficial for industrial production.

专利号:CN-107118161-B
优先权日:2017-05-05
标 题:Synthesis method of 2-n-propyl-4-methylbenzimidazole-6-carboxylic acid