CAS: 138109-49-6; Magnesium,1,3-Dimethoxybenzene-6-Ide,Bromide

上下游产品

1-Bromo-2,4-dimethoxybenzene Osmorhizole -5α-estr-9-ene-5,17β-diol11β-(2,4-dimethoxyphenyl)-3,3-2,2-dimethyl-1,3-propanediylbis(oxy)-5α-estr-9-ene-5,17β-diol (E)-1-phenyl-3-(2,4-dimethoxyphenyl)-1-propene (+/-)-N-(2'-fluorophenyl)-2-(α-hydroxy-2',4'-dimethoxybenzyl)pyrrole

专利信息

专利号:US-7193077-B2
优先权日:2003-08-30
标 题 :Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.

专利号:US-7427679-B2
优先权日:2003-08-30
标 题:Precursors for two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively, R 1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R 2 or R 3 is a hydroxyl protecting group; and the other of R 2 or R 3 is a reactive group capable of reacting with a reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is a triaryl methyl group having the structure (V) n nwherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R 4 , R 5 and R 6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R 4 , R 5 , and R 6 is an aryl group other than phenyl and other than substituted phenyl.

专利号:US-7417139-B2
优先权日:2003-08-30
标 题 :Method for polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H; DELLINGER GERALDINE F
权利人:AGILENT TECHNOLOGIES INC
摘要:Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively R1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R2 or R3 is a hydroxyl protecting group; and the other of R2 or R3 is a reactive group capable of reacting with the reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is the exocyclic amine triaryl methyl protecting group.

专利号:US-7576245-B2
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
发明人：ZHANG WEI; LUO ZHIYONG
权利人:FLUOROUS TECHNOLOGIES INC
摘要:The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.

专利号:US-2004073054-A1
优先权日:2002-07-11
标 题 :New fluorous tagging and scavenging reactants and methods of synthesis and use thereof

专利号:US-2006128957-A1
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof