CAS: 135042-17-0; (2R,4S)-1-Tert-Butyl 2-Methyl 4-Hydroxypyrrolidine-1,2-Dicarboxylate

上下游产品

CAS号84520-67-2 (2S,4R)-B°C-4-甲... | CAS号142347-81-7 反式4-羟基-D-脯氨酸盐酸盐 | CAS号256487-77-1 N-B°C-4-羰基-L-脯氨酸甲酯 | CAS号1123307-53-8 2,5-Dibromo-N-[... | CAS号77450-03-4 (2R,4S)-4-羟基-2-...

N-Boc-顺式-4-羟基-L-脯氨酸甲酯置于sodium Azide,Crown Ether,三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 24.0H,反应生成N-Boc-反式-4-羟基-D-脯氨酸甲酯
参考文献:受保护的3-叠氮基和4-叠氮基脯氨酸及其前体的短而高效的合成.
标题:受保护的3-叠氮基和4-叠氮基脯氨酸及其前体的短而高效的合成.
摘要:[结构:见正文]据报道,保护的顺式和反式3-叠氮基-L-脯氨酸以及顺式和反式-4-叠氮基-L-和-D-脯氨酸的合成方法得到了改进.这些化合物已经由二苯基磷酰基叠氮化物在mitsunobu条件下由相应的羟脯氨酸前体合成.基于新的内酯开放反应和在非常温和的条件下对硝基苯甲酸酯水解,描述了这些前体的短而高效的合成.
Doi:10.1021/ol0161054

专利信息

专利号:US-7691843-B2
优先权日:2002-07-11
标 题 :N-hydroxyamide derivatives possessing antibacterial activity
发明人：RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM
权利人:PFIZER
摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.