CAS: 13024-90-3; 2-(4-Chlorophenyl)-5-Methyl-1H-Pyrazol-3(2H)-One

相似化合物

13124-17-9 89-25-8 14580-22-4

上下游产品

ethyl acetoacetate N-4-chlorophenylhydrazine 5-Methyl-4-(1-methylethylidene)-2-(4'-chlorophenyl)-2,4-dihydro-3H-pyrazol-3-one hydrazine carboxamide 2-(4-chloro-phenyl)-5-methyl-4-thiophen-2-ylmethylene-2,4-dihydro-pyrazol-3-one 2-(4-chloro-phenyl)-5-methyl-4-(1-thiophen-2-yl-ethylidene)-2,4-dihydro-pyrazol-3-one 2-(4-chloro-phenyl)-5-methyl-4-(5-nitro-furan-2-ylmethylene)-2,4-dihydro-pyrazol-3-one 4-benzo[1,3]dioxol-5-ylmethylene-2-(4-chloro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one

📜对氯苯胺置于盐酸,溶剂黄146,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 12.67H,反应生成1-(4-氯苯基)-3-甲基-2-吡唑啉-5-酮
参考文献:通过活性导向组合化学合成策略发现新型人磷酸甘油酸脱氢酶抑制剂
标题:通过活性导向组合化学合成策略发现新型人磷酸甘油酸脱氢酶抑制剂
摘要:丝氨酸是从头合成嘌呤和脱氧胸苷所必需的一碳单元的来源,在癌细胞的生长中起着至关重要的作用.磷酸甘油酸脱氢酶 (Phgdh) 催化丝氨酸从头生物合成中的第一个限速步骤,已成为治疗癌症的有希望的靶点.在这里,我们从基于酶促测定的内部小分子库的筛选中确定了h-G6作为潜在的 Phgdh 抑制剂.我们采用了活性导向的组合化学合成策略来优化这种命中化合物.发现化合物b36是非竞争性和最有前途的化合物,其对 Phgdh 的ic 50值为 5.96 +/-0.61 μm.化合物b36抑制人乳腺癌和卵巢癌细胞的增殖,减少细胞内丝氨酸合成,破坏dna合成,并诱导细胞周期停滞.总的来说,我们的结果表明b36是一种新型的 Phgdh 抑制剂,它可能是一种有前景的调节丝氨酸合成途径的调节剂,并且可能是一种潜在的抗癌先导物,值得进一步探索.
Doi:10.1016/j.Bioorg.2021.105159

专利信息

专利号:US-5233044-A
优先权日:1989-06-08
标题:Active esters for solid phase peptide synthesis
发明人：HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.

专利号:EP-0401797-A1
优先权日:1989-06-08
标 题:Active esters for solid phase peptide synthesis
发明人：HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystal­line, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectro­photometric monitoring and automation of peptide synthesis.

专利号:CN-107382866-A
优先权日:2017-03-27
标题 :A kind of gossypol-edaravone condensate with anti-tumor activity and its synthesis method