专利号:US-2023313255-A1 优先权日:2020-07-15 标题:Massively Parallel Enzymatic Synthesis of Polynucleotides 发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER 权利人:DNA SCRIPT 摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.
专利号:US-2013123543-A1 优先权日:2010-04-14 标 题:Polyacetylenic Compounds with Anti-Fungal Activity Derived from the Bacterium Collimonas and Methods for the Preparation and Identification Thereof 发明人:FRITSCHE KATHRYN; LEVEAU JOHANNES HENRICUS JOSEPHUS; DE BOER WIETSE; VAN VEEN JOHANNES ANTONIE 权利人:FRITSCHE KATHRYN; LEVEAU JOHANNES HENRICUS JOSEPHUS; DE BOER WIETSE; VAN VEEN JOHANNES ANTONIE; NETHERLANDS INST OF ECOLOGY 摘要:The present invention relates to isolated nucleic acid sequences involved in, or capable of the biosynthesis of polyacetylenic compounds with anti-fungal activity and especially isolated nucleic acid sequences derived from Collimonas fungivorans . Further, the present invention relates to methods for identifying the present isolated nucleic acids, the use thereof for identification of homologous nucleic acids in other organisms or the use thereof for the biosynthesis of polyacetylenic compounds with anti-fungal activity. Further, the present invention relates to novel polyacetylenic compounds with anti-fungal activity. Specifically, the present invention relates to isolated nucleic acids encoding one or more proteins involved in the synthesis of a polyacetylenic compound with antifungal activity wherein said isolated nucleic acid comprises a nucleic acid sequence having at least 70%, preferably at least 80%, more preferably at least 90%, most preferably at least 95% identity with SEQ ID No. 1.
专利号:US-6048529-A 优先权日:1991-12-19 标 题 :PVA or PEG conjugates of peptides for epitope-specific immunosuppression 发明人:ATASSI M ZOUHAIR; ASHIZAWA TETSUO 摘要:The invention relates to a procedure for synthesis of well-defined conjugates of peptides to the tolerogenic polymer monomethoxypolyethylene glycol (mPEG) or polyvinyl alcohol (PVA). This method results in the preparation of conjugates in which one molecule of tolerogenic polymer is specifically coupled to one or the other or both of the termini of an otherwise unaltered peptide molecule. A synthetic peptide synthesized using this method and corresponding to a myasthenogenic region of an acetylcholine receptor was conjugated to monomethoxypolyethylene glycol. Injection of animals with the mPEG-conjugate and subsequent immunization with whole receptor suppressed the development of experimental autoimmune myasthenia gravis (EAMG) by electrophysiological criteria. Specifically-conjugated, tolerogenic peptides are also disclosed for diseases as diverse as ragweed pollen allergy and Grave's disease.
专利号:US-9976179-B2 优先权日:2011-03-30 标 题 :Nucleic acid sequencing technique using a pH-sensing agent 发明人:HAUSHALTER ROBERT C 权利人:PARALLEL SYNTHESIS TECH; PARALLEL SYNTHESIS TECH INC 摘要:The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.
专利号:US-2006074032-A1 优先权日:2000-11-29 标题 :Synthesis and separation of optically active isomers of erythromycin and their biological actions 发明人:SOMBERG JOHN; RANADE VASANT 权利人:ACADEMIC PHARM INC 摘要:The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.
专利号:US-8507219-B2 优先权日:1997-11-25 标 题 :Method of treating inflammation with statins 发明人:SINGH INDERJIT 权利人:SINGH INDERJIT; MUSC FOUND FOR RES DEV 摘要:The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.
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