2-氯-2,4,4-三甲基戊烷置于乙醚,Magnesium体系中,化学反应生成叔辛胺 参考文献:Manufacture Of Organic Amines 标题:Manufacture Of Organic Amines
专利信息
专利号:US-11655255-B2 优先权日:2022-10-17 标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein 发明人:ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG 权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG 摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)
专利号:EP-0062322-A1 优先权日:1981-04-03 标 题 :Improved process for synthesis of hindered amine stabilizers for polymeric materials 发明人:LAI JOHN TA-YUAN 权利人:GOODRICH CO B F 摘要:Process for the synthesis of hindered polysubstituted α-amino acetamides by reaction of a secondary amine with an α-halo acetamide in a basic organic reaction medium and in the presence of a phase transfer catalyst. The product thus obtained can comprise a multifunctional compound having one or more hindered amino moieties. These compounds are highly effective as UV stabilizers in a variety of plastics, especially the alpha monoolefins.
专利号:US-6423871-B1 优先权日:1999-02-26 标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines 发明人:JUNG KYUNG WOON 权利人:UNIV SOUTH FLORIDA 摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.
专利号:WO-0050377-A1 优先权日:1999-02-26 标 题:Efficient synthesis of secondary amines by selective alkylation of primary amines 发明人:JUNG KYUNG WOON 权利人:UNIV SOUTH FLORIDA 摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23 °C; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73 % yield.
专利号:US-2009318592-A1 优先权日:2005-10-11 标 题 :Process for the Synthesis of Amine Ethers 发明人:FREY MARKUS; BROENNIMANN VALERIE 权利人:CIBA GEIGY CORP 摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.
专利号:US-2007191516-A1 优先权日:2004-03-15 标题 :Process for the synthesis of amine ethers 发明人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS 权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS 摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.
参考标题:Reactions Of N-Polyfluorophenylcarbonimidoyl Dichlorides With Primary And Secondary Amines. Kinetics And Mechanism. Synthesis Of Polyfluorinated Carbodiimides, Chloroformamidines, Guamidines And Benzimidazoles. 作者:I.V. Kolesnikova,T.D. Petrova,V.E. Platonov,V.A. Mikhailow,A.A. Popov,V.A. Savelova |发布日期:1988.8 摘要:N-Polyfluorophenylcarbonimidoyl Dichlorides With Primary And Secondary Aliphatic And Aromatic Amines Have Been Studied. With Primary Aliphatic Amines, The Reactions Led To Carbodiimides Or Guanidines, Depending On The Amount Of Amine. The Carbodiimides Obtained Reacted With Amines To Form Guanidines. The Reactions With Primary Aromatic Amines Produced Only Triarylguanidines. N-Pentafluorophenyllcarbonimidoyl
合成参考文献
摘要:Drabowicz, J.; Krasowska, D.; Wicha, J., Science of Synthesis, (2009) 48, 257. 摘要:National Technical Information Service., OTS0530659-1