专利号:US-9688644-B2 优先权日:2009-04-30 标 题 :Synthesis of Tetracyclines and intermediates thereto 发明人:MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.
专利号:US-2022298136-A1 优先权日:2019-08-21 标题 :Process for synthesis of pyrazolidinone compounds 发明人:MATHUR SUCHET SARAN; JAIN NANDKUMAR JANARDAN; MORE MAHENDRA MAHIPAT 权利人:GHARDA CHEMICALS LTD 摘要:A process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound, is provided. The process is simple, economical, and produces alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate with a comparatively high yields.
专利号:WO-2021033165-A1 优先权日:2019-08-21 标 题:Process for synthesis of pyrazolidinone compounds 发明人:MATHUR SUCHET SARAN; MHATRE HRIDAYNATH VISHWANATH; PEDHAVI VISHAL PARSHURAM 权利人:GHARDA CHEMICALS LTD 摘要:The present disclosure relates to a process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound. The process of the present disclosure is simple, economical, and produces alkyl 2-(3-5 chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate with a comparatively high yields.
专利号:US-4443310-A 优先权日:1981-03-12 标题:Photoinitiated synthesis of mercaptans 发明人:ARRETZ EMMANUEL; LANDOUSSY CLAUDE; MIRASSOU ALFRED; OLLIVIER JEAN 权利人:ELF AQUITAINE 摘要:Improvement in the photoinitiated synthesis of mercaptans, in which an ethylenic compound is treated with hydrogen sulphide, preferably under pressure, in the presence of ultraviolet radiation and a photoinitiator involves the use of a xanthenic compound, possibly substituted, as the initiator. Preferably, the xanthenic compounds is employed in conjunction with an organic compound of an element of Group V A of the Periodic Classification of the Elements.
专利号:US-8053522-B2 优先权日:2006-02-28 标题 :Synthesis of polyester-graft-poly(meth)acrylate copolymers 发明人:LOEHDEN GERD; BALK SVEN; BRAND THORSTEN; BRENNER GABRIELE; ARNOLD THOMAS; BAUMANN CORNELIA 权利人:EVONIK ROEHM GMBH 摘要:The present invention relates to a novel synthesis of (meth)acrylate-grafted polyesters and their action as compatibilizers.
专利号:US-7384739-B2 优先权日:2001-11-14 标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof 发明人:KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI 权利人:TOYO BOSEKI 摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.
1: Clasen SH, Müller CMO, Parize AL, Pires ATN. Synthesis and characterization of cassava starch with maleic acid derivatives by etherification reaction. Carbohydr Polym. 2018 Jan 15;180:348-353. doi: 10.1016/j.carbpol.2017.10.016. Epub 2017 Oct 6. doi: 10.1248/bpb.b15-00683. Epub 2015 Dec 2. doi: 10.1021/jp5130052. Epub 2015 Jan 29. doi: 10.1111/j.1600-0536.2009.01539.x. Epub 2006 Nov 19.
合成参考文献
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