CAS: 100-70-9; Picolinonitrile

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CAS号873-69-8 2-吡啶甲醛肟 | CAS号109-04-6 2-溴吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1121-60-4 吡啶-2-甲醛 | CAS号1452-77-3 吡啶酰胺 | CAS号586-98-1 吡啶甲醇 | CAS号151-50-8 氰化钾 | CAS号355023-81-3 t-butyl α-anti-... | CAS号75-86-5 丙酮氰醇 | CAS号609770-35-6 2-(叠氮基甲基)吡啶 | CAS号1014720-73-0 2-(2-吡啶基)-6-氯-4-氨基嘧啶 | CAS号108018-18-4 1-Propanone,1-(... | CAS号109814-50-8 4H-吡唑[1,2-A]吡嗪-4-八氢酮 | CAS号109660-12-0 2-(4,5-二氢-4,4-二... | CAS号3238-55-9 2-丙酰基吡啶 | CAS号3731-51-9 2-(氨甲基)吡啶 | CAS号3939-15-9 6-氟-2-氰基吡啶 | CAS号58481-14-4 2-氰基异烟酸乙酯 | CAS号97483-79-9 6-氰基-吡啶-2-羧酸乙酯 | CAS号2176-62-7 五氯吡啶

T-Butyl α-Anti-{[(S)-α-Methylbenzyl]Carbamoyl}Oximino-α-(2-Pyridyl)Acetate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 36.0H,以99%的收率获得2-氰基吡啶
参考文献:Relative Reactivity Of Anti-And Syn-Oximino Carbonates And Carbamates Of 2-Pyridylacetic Acid Esters
标题:Relative Reactivity Of Anti-And Syn-Oximino Carbonates And Carbamates Of 2-Pyridylacetic Acid Esters
摘要:[graphics]Anti-Oximes Of 2-Pyridylacetic Acid Esters Are Rapidly Transformed To Pyridine-2-Carbonitrile Under A Variety Of Conditions While Syn-Oximes Bearing Tert-Butyl Esters Can Be Conveniently Deprotected To The Corresponding Carboxylic Acid With Subsequent Fragmentation To The Nitrile.
Doi:10.1021/ol015737N

专利信息

专利号:US-2024101506-A1
优先权日:2021-01-26
标 题 :Continuous process for the synthesis of dimethyl carbonate over a cerium-based catalyst formulation
发明人：SRINIVAS DARBHA; BOKADE VIJAY VASANT; NIPHADKAR PRASHANT SURESH; PULIKKEEL UNNIKRISHNAN; PARMAR SNEHALKUMAR; AMTE VINAY; SENGUPTA SURAJIT; DAS ASIT KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a continuous process for the synthesis of dimethyl carbonate from methanol and carbon dioxide over a ceria-based mixed metal oxide-silica catalyst formulation in the presence of a dehydrating or water trapping compound (2-Cyanopyridine).

专利号:US-8299206-B2
优先权日:2007-11-15
标题:Method of synthesis of morpholino oligomers
发明人：FOX CHRISTINA MARY JOSEPHINE; WELLER DWIGHT D
权利人:FOX CHRISTINA MARY JOSEPHINE; WELLER DWIGHT D; AVI BIOPHARMA INC
摘要:Improved methods are described for solid-phase synthesis of morpholino oligomers, in which a protected morpholino ring nitrogen is deprotected between coupling steps using a heterocyclic amine salt in a trifluoroethanol-containing solvent, where the salt is a salt of a heterocyclic amine, having a pKa in the range of 1-4 in its protonated form, with an acid selected from a sulfonic acid, trifluoroacetic acid, and hydrochloric acid. Examples are 3-chloropyridinium methanesulfonate (CPM) and 4-cyanopyridinium trifluoroacetate (CYTFA).

专利号:US-5239023-A
优先权日:1990-10-24
标 题 :Process for the synthesis of crystallizable 3,4-polyisoprene and isoprene-butadiene copolymers having high vinyl contents
发明人：HSU WEN-LIANG; HALASA ADEL F
权利人:GOODYEAR TIRE & RUBBER
摘要:Crystallizable 3,4-polyisoprene and isoprene-butadiene copolymers having high vinyl contents can be synthesized in organic solvents to quantitative yields after short polymerization times by utilizing the catalyst systems of this invention. The 3,4-polyisoprene made utilizing this catalyst system is strain crystallizable and can be employed in tire treads which provide improved traction and improved cut growth resistance. This invention specifically discloses a process for the synthesis of 3,4-polyisoprene which comprises polymerizing isoprene monomer in an organic solvent at a temperature which is within the range of about -10 DEG C. to about 100 DEG C. in the presence of a catalyst system which is comprised of (a) an organoiron compound which is soluble in the organic solvent, wherein the iron in the organoiron compound is in the +3 oxidation state, (b) a partially hydrolyzed organoaluminum compound which was prepared by adding a protonic compound selected from the group consisting of water, alcohols and carboxylic acids to the organoaluminum compound, and (c) a chelating aromatic amine; wherein the molar ratio of the chelating amine to the organoiron compound is within the range of about 0.1:1 to about 1:1, wherein the molar ratio of the organoaluminum compound to the organoiron compound is within the range of about 5:1 to about 200:1, and wherein the molar ratio of the protonic compound to the organoaluminum compound is within the range of about 0.001:1 to about 0.2:1.

专利号:US-5061765-A
优先权日:1990-10-22
标题:Process for the synthesis of a high vinyl isoprene-butadiene copolymer
发明人：HSU WEN-LIANG; HALASA ADEL F
权利人:GOODYEAR TIRE & RUBBER
摘要:Isoprene-butadiene copolymers having high vinyl contents can be synthesized in organic solvents to high yields after short polymerization times by utilizing the process of this invention. The isoprene-butadiene copolymers made utilizing the process of this invention have a glass transition temperature which is within the range of about 0° C. to about -60° C. and can be employed in tire treads which provide improved traction and improved cut growth resistance. This invention specifically discloses a process for the synthesis of isoprene-butadiene copolymers having a high vinyl content which comprises copolymerizing isoprene monomer and butadiene monomer in an organic solvent at a temperature which is within the range of about -10° C. to about 100° C. in the presence of a catalyst system which is comprised of (a) an organoiron compound, (b) an organoaluminum compound, (c) a chelating aromatic amine, and (d) a protonic compound; wherein the molar ratio of the chelating amine to the organoiron compound is within the range of about 0.1:1 to about 1:1, wherein the molar ratio of the organoaluminum compound to the organoiron compound is within the range of about 5:1 to about 200:1, and wherein the molar ratio of the protonic compound to the organoaluminum compound is within the range of about 0.001:1 to about 0.2:1.

专利号:US-5151398-A
优先权日:1990-10-24
标 题 :Catalyst for the synthesis of crystalline 3,4-polyisoprene
发明人：HSU WEN-LIANG; HALASA ADEL F
权利人:GOODYEAR TIRE & RUBBER
摘要:Crystallizable 3,4-polyisoprene can be synthesized in organic solvents to quantitative yields after short polymerization times by utilizing the catalyst systems of this invention. The 3,4-polyisoprene made utilizing this catalyst system is strain crystallizable and can be employed in tire treads which provide improved traction and improved cut growth resistance. This invention specifically discloses a process for the synthesis of 3,4-polyisoprene which comprises polymerizing isoprene monomer in an organic solvent at a temperature which is within the range of about -10° C. to about 100° C. in the presence of a catalyst system which is comprised of (a) an organoiron compound, (b) an organoaluminum compound, (c) a chelating aromatic amine, and (d) a protonic compound; wherein the molar ratio of the chelating amine to the organoiron compound is within the range of about 0.1:1 to about 1:1, wherein the molar ratio of the organoaluminum compound to the organoiron compound is within the range of about 5:1 to about 200:1, and wherein the molar ratio of the protonic compound to the organoaluminum compound is within the range of about 0.001:1 to about 0.2:1.

专利号:US-12428656-B2
优先权日:2020-02-28
标题 :Nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid
发明人：XUE YAPING; XIONG NENG; LI QIAN; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:The present invention provides a nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid, the nitrilase mutant is obtained by mutating one or two of the amino acids at position 180 and 205 of the amino acid sequence shown in SEQ ID No. 2. In the present invention, by semi-rational design and protein molecular modification, the specific enzyme activity of the nitrilase double mutant AcN-G180D/A205C was increased by up to 1.6 folds, and the conversion rate>99%. And the reaction time was shortened to a quarter of the original using the recombinant Escherichia coli containing the nitrilase mutant to hydrolyze 1-cyanocyclohexylacetonitrile at high temperature (50° C.). Therefore, the mutants obtained by the present invention have a good application prospect in efficiently catalyzing 1-cyanocyclohexylacetonitrile to synthesize gabapentin intermediate, 1-cyanocyclohexyl acetic acid.