专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:WO-2025044766-A1 优先权日:2023-08-31 标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide 发明人:SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN 权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD 摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.
专利号:US-11542269-B2 优先权日:2018-01-03 标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof 发明人:CHOI HYEONG-WOOK; FANG FRANCIS G 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
专利号:US-4000169-A 优先权日:1975-01-27 标题 :Asymmetric synthesis of optically active compounds 发明人:CHAN KA-KONG; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:Asymmetric synthesis of optically active 3,7,11-trimethyl-dodecan-1-ol, an intermediate for producing optically active vitamin E, from isovaleraldehyde or prenal including intermediates in this synthesis.
专利号:US-4400550-A 优先权日:1982-02-12 标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal 发明人:BISHOP CLYDE E; MORROW GARY W 权利人:ALBANY INT CORP 摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.
专利号:US-8569452-B2 优先权日:2011-02-17 标题:Preparation of phalloidin and its derivatives 发明人:LIU BAOSHENG; ZHANG JIANHENG 权利人:LIU BAOSHENG; ZHANG JIANHENG; AMERICAN PEPTIDE COMPANY INC 摘要:The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.
参考标题:An Efficient Mechanochemical Synthesis Of Amides And Dipeptides Using 2,4,6-Trichloro-1,3,5-Triazine And Pph3 作者:Chuthamat Duangkamol,Subin Jaita,Sirilak Wangngae,Wong Phakhodee,Mookda Pattarawarapan 摘要:Mechanochemical Synthesis Of Amides From Carboxylic Acids Has Been Developed Through An In Situ Acid Activation With 2,4,6-Trichloro-1,3,5-Triazine And A Catalytic Amount Of Pph3. Under Room Temperature Solvent-Drop Grinding Of The Reactants In The Presence Of An Inorganic Base, A Variety Of Carboxylic Acids Including Aromatic Acids, Aliphatic Acids, And N-Protected α-Amino Acids Undergo Amidation To Afford
合成参考文献
摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 78. 摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 368. 摘要:Arévalo, M. J.; Lavilla, R., Science of Synthesis: Multicomponent Reactions, (2013) 1, 312. 摘要:Chemler, S. R.; Kennedy-Ellis, J. J., Science of Synthesis: Special Topics, (2022) 1, 108. 摘要:S. L. Gupta and M. C. Gupta, J. Indian Chem. Soc. 40, 321 (1963).