CAS: 931-48-6; Ethynylcyclohexane
该化合物是一种环氧乙烷衍生物,具有苯乙烯功能组,使其成为有机合成中有价值的中间体,其结构将环的稳定性与烷的活性结合起来,使环的稳定性能够应用于交叉反应,聚合和制药研究.该化合物的硬性环氧基质能够增强催化工艺的消毒控制,而终端烷允许选择性地实现功能化.乙型六氯环己烷通常用于制作先进材料,离心和生物活性分子.其高纯度和一贯性能使其适合于精确的化学合成和工业规模的应用.
相似化合物
17715-00-3 141345-08-6 1866646-62-9物理性质
MSDS等安全信息
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号246023-17-6 α-(dichlorometh... | CAS号56772-65-7 2,2-dichloroeth... | CAS号823-76-7 乙酰基环己烷 | CAS号81602-60-0 1,2-dibromo-1-c... | CAS号67404-69-7 (Z)-1-iodo-2-cy... | CAS号66270-60-8 2-cyclohexyleth... | CAS号108-85-0 溴代环己烷 | CAS号29552-15-6 4-chloro-2-meth... | CAS号17615-02-0 1-cyclohexyl-2-... | CAS号90965-06-3 (1-重氮基-2-氧代丙基)膦酸二甲酯 | CAS号104875-64-1 2-cyclohexyleth... | CAS号56077-28-2 2-溴-1-环己基乙酮 | CAS号1892-09-7 2-chloro-1-cycl... | CAS号21293-05-0 [(1E,3Z)-4-cycl... | CAS号18736-95-3 1-环己基-1-丙炔 | CAS号823-76-7 乙酰基环己烷 | CAS号287477-26-3 2-(2-cyclohexyl... | CAS号6765-39-5 1-十七碳烯 | CAS号1367369-82-1 (Z)-1-chloro-1-...合成工艺路线路线简述
- 合成目标产物 Cyclohexylacetylene 主要起始原料 1-Cyclohexylethan-1-One
- 56772-65-7 = 931-48-6
反应条件:1.1 Reagents: Methyllithium Solvents: Diethyl Ether,Tetrahydrofuran1.2 Reagents: Ammonium Chloride Solvents: Water
标题:A New And Practical Synthesis Of Vinyl Dichlorides Via A Non-Wittig-Type Approach
作者:Wang,Zhe; Campagna,Silvio; Xu,Guoyou; Pierce,Michael E.; Fortunak,Joseph M.; Et Al
参考文献:Tetrahedron Letters 日期:2000 卷标:41(21) 页码:4007-4009]
60754-49-6 = 931-48-6
反应条件:1.1 Reagents: Samarium Iodide (Smi2) Solvents: Benzene,Hexamethylphosphoramide
标题:Generation Of Alkylidenecarbenes From 1,1-Dibromoalk-1-Enes By The Reaction With Samarium Diiodide In Hexamethylphosphoric Triamide-Benzene
作者:Kunishima,Munetaka; Hioki,Kazuhito; Ohara,Takashi; Tani,Shohei
参考文献:Journal Of The Chemical Society 日期:1992 卷标:(3) 页码:219-20]
823-76-7 = 931-48-6
反应条件:1.1 Reagents: 1,1,2,2,3,3,4,4,4-Nonafluoro-1-Butanesulfonyl Fluoride,N′′′-[p,P-Bis(Dimethylamino)-N-(1,1-Dimethylethyl)Phosphinimyl]-N,N,N′,N′,N′′,N′... Solvents: Dimethylformamide; 18 H,-10 °C; 1 - 2 H,Rt
标题:Thieme Chemistry Journal Awardees - Where Are They Now? A General One-Step Synthesis Of Alkynes From Enolisable Carbonyl Compounds
作者:Lyapkalo,Ilya M.; Vogel,Michael A. K.; Boltukhina,Ekaterina V.; Vavrik,Jiri
参考文献:Synlett 日期:2009 卷标:(4) 页码:558-561]
131292-27-8 = 931-48-6 [标题:Reaction Conditions
标题:Convenient Two-Step Conversion Of Acid Chlorides To Terminal Alkynes
作者:Aitken,R. Alan; Seth,Shirley
参考文献:Synlett 日期:1990 卷标:(4)]
17615-02-0 = 931-48-6 [标题:Reaction Conditions
标题:Product Class 8: Linear Alkynes: Synthesis By Elimination
作者:Sankararaman,S.
参考文献:Science Of Synthesis 日期:2008 卷标:43 页码:435-467]
1111-64-4 + 133986-35-3 = 931-48-6
反应条件:1.1 -1.2 Catalysts: Iodine
标题:Acetylene
作者:Bhattacharya,Samit K.; Stelmach,John E.; Winkler,Jeffrey D.
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]
6867-30-7 = 931-48-6
反应条件:1.1 Reagents: (T-4)-Trihydro(Tetrahydrofuran)Boron Solvents: Tetrahydrofuran; Overnight,25 °C1.2 2 H1.3 Reagents: Iodine Solvents: Tetrahydrofuran; 1.5 H,-78 °C; Rt1.4 Reagents: Sodium Hydroxide Solvents: Water; 15 Min
标题:The Synthesis And Reactions Of Alkynylboranes And "Ate" Complexes
作者:Sinclair,James Angus
参考文献:1976]
56772-65-7 = 931-48-6
反应条件:1.1 Reagents: Methyllithium Solvents: Diethyl Ether,Tetrahydrofuran1.2 Reagents: Ammonium Chloride Solvents: Water
标题:Novel Method For The Preparation Of Monosubstituted Acetylenes,Especially Cyclopropylacetylene
参考文献:World Intellectual Property Organization]
246023-17-6 = 931-48-6
反应条件:1.1 Reagents: Methyllithium Solvents: Diethyl Ether,Tetrahydrofuran1.2 Reagents: Ammonium Chloride Solvents: Water
标题:An Alternative Approach For The Conversion Of Aldehydes To Terminal Alkynes
作者:Wang,Zhe; Yin,Jianguo; Campagna,Silvio; Pesti,Jaan A.; Fortunak,Joseph M.
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(18) 页码:6918-6920]
67404-69-7 = 931-48-6
反应条件:1.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 12 H,80 °C
标题:Terminal Alkynes From Aldehydes Via Dehydrohalogenation Of (Z)-1-Iodo-1-Alkenes With Tbaf
作者:Beshai,Mira; Dhudshia,Bhartesh; Mills,Ryan; Thadani,Avinash N.
参考文献:Tetrahedron Letters 日期:2008 卷标:49(48) 页码:6794-6796]
= 931-48-6
反应条件:1.1 Reagents: Methyllithium Solvents: Tetrahydrofuran1.2 Reagents: Ammonium Chloride1.3 Solvents: Hexane1.4 Solvents: Hexane
标题:A Practical Preparation Of Terminal Alkynes From Aldehydes
作者:Wang,Zhe; Campagna,Silvio; Yang,Kaihong; Xu,Guoyou; Pierce,Michael E.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2000 卷标:65(6) 页码:1889-1891]
60754-49-6 = 931-48-6
反应条件:1.1 Reagents: Samarium Iodide (Smi2) Solvents: Benzene,Hexamethylphosphoramide
标题:Reductions With Samarium(Ii) Iodide
作者:Molander,Gary A.
参考文献:Organic Reactions (Hoboken 日期:1994 卷标:46]
17615-02-0 = 931-48-6 [标题:Reaction Conditions
标题:Flash Vacuum Pyrolysis Of Stabilized Phosphorus Ylides. Part 1. Preparation Of Aliphatic And Terminal Alkynes
作者:Aitken,R. Alan; Atherton,J. Ian
参考文献:Journal Of The Chemical Society 日期:1994 卷标:(10) 页码:1281-4]
56772-65-7 = 931-48-6 [标题:Reaction Conditions
标题:Reaction Of Cyclohexylacetylene With Lower Saturated Monobasic Acids
作者:Bol'Shukhin,A. I.; Egorov,A. G.
参考文献:Zhurnal Obshchei Khimii 日期:1957 卷标:27 页码:1185-7]
4545-18-0 = 931-48-6
反应条件:1.1 Reagents: Potassium Tert-Butoxide,Water,Cuprous Chloride Solvents: Dimethylformamide; 12 H,120 °C
标题:Synthesis Of Aromatic Terminal Allenes And Aliphatic Terminal Alkynes From Hydrazones Using Calcium Carbide As An Acetylene Source
作者:Gao,Lei; Li,Zheng
参考文献:Organic Chemistry Frontiers 日期:2020 卷标:7(4) 页码:702-708]
1111-64-4 + 133986-35-3 = 931-48-6
反应条件:1.1 -1.2 Reagents: Iodine
标题:Acetylene
作者:Bhattacharya,Samit K.; Stelmach,John E.; Winkler,Jeffrey D.; Arrington,Kenneth L.
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2008 卷标:1 页码:1-6]
196789-87-4 = 931-48-6
反应条件:1.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,Rt
标题:Direct Acylation And Alkynylation Of Hydrocarbons Via Synergistic Decatungstate Photo-Hat/nickel Catalysis
作者:Liu,Wenfeng; Ke,Yang; Liu,Chuhan; Kong,Wangqing
参考文献:Chemical Communications (Cambridge 日期:2022 卷标:58(85) 页码:11937-11940]
60754-49-6 = 931-48-6 [标题:Reaction Conditions
标题:Synthesis Of Linear Alkynes By Rearrangement
作者:Krueger,A.
参考文献:Science Of Synthesis 日期:2008 卷标:43 页码:469-554]
6867-30-7 = 931-48-6 [标题:Reaction Conditions
标题:Product Subclass 39: Tetraaryl- And Tetraalkylborates And Related Organometallic Compounds
作者:Kaufmann,D. E.; Koester,M.
参考文献:Science Of Synthesis 日期:2004 卷标:6 页码:1217-1233]
823-76-7 = 931-48-6
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Nitrogen1.2 Reagents: Diethyl Chlorophosphate1.3 Reagents: Lithium Diisopropylamide
标题:Conversion Of Methyl Ketones Into Terminal Alkynes: (E)-Buten-3-Ynyl-2,6,6-Trimethyl-1-Cyclohexene
作者:Negishi,Ei-Ichi; King,Anthony O.; Tour,James M.
参考文献:Organic Syntheses 日期:1986 卷标:64 页码:44-9
📜乙酰基环己烷置于全氟丁基磺酰氟,1-叔丁基-2,2,4,4,4-五(二甲氨基)-2λ5,4λ5-连二(磷氮基化合物)体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以80%的收率获得产物环己基乙炔
参考文献:Thieme Chemistry Journal 获奖者-他们现在在哪里从可烯化羰基化合物一步法合成炔烃
标题:Thieme Chemistry Journal 获奖者-他们现在在哪里从可烯化羰基化合物一步法合成炔烃
摘要:通过将羰基官能团转化为烯醇九氟甲磺酸酯中间体,然后消除以得到 Cc 三键,从羰基化合物中以非常好至极好的分离产率获得了末端和内部乙炔.磷腈碱与温和亲电子的九氟丁烷-1-磺酰氟相结合均匀地诱导了一锅法转化.该方法是迄今为止报道的方法中最通用的,因为它适用于无环酮和醛.只有适度的动力学区域选择性有利于从甲基正烷基酮实现的 Alk-1-Yne 代表了该方法的局限性.在所有其他情况下,都获得了单独的炔烃产品.
DOI:10.1055/s-0028-1087919
海关参考信息
- 2901292000-乙炔
2902300000-甲苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11891351-B2
优先权日:2020-03-20
标 题 :Synthesis of capsaicin derivatives
发明人：LAGER ERIK
权利人:AXICHEM AS
摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.
专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人：LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.
专利号:US-6288297-B1
优先权日:1998-10-01
标 题:Process for the preparation of cyclopropylacetylene
发明人：WANG ZHE; YIN JIANGUO; FORTUNAK JOSEPH M; CAMPAGNA SILVIO
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor. In the process, for example, cyclopropane carboxaldehyde is alkylated to form 1,1,1-trichloro-2-cyclopropyl-ethanol; which in turn is hydroxy protected to form 1,1,1-trichloro-2-cyclopropylethyltosylate; which in turn undergoes elimination to form cyclopropyl acetylene. This improvement provides for high conversion of inexpensive, readily available starting materials into cyclopropylacetylene, high overall yields and can be conducted on an industrial scale.
专利号:US-2007082923-A1
优先权日:2005-10-05
标题:Process for the synthesis of compounds for selectin inhibition
发明人：WANG YOUCHU
权利人:WANG YOUCHU
摘要:The present teachings relate to the field of anti-inflammatory substances, and more particularly to the preparation of compounds that act as antagonists of the mammalian adhesion proteins known as selecting. In some embodiments, the present teachings provide methods for preparing compounds for treating selectin-mediated disorders that have the formula VI: n n nwherein R 1 , R 2 , R 3 , p, and q are defined herein.
专利号:US-8487109-B2
优先权日:2007-07-03
标题:Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
发明人：RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE
权利人:RKYEK OMAR; NAZARE MARC; LINDENSCHMIDT ANDREAS; URMANN MATTHIAS; HALLAND NIS; ALONSO JORGE; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), n nwherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Investigations On Gold‐catalyzed Thioalkyne Activation Toward Facile Synthesis Of Ketene Dithioacetals作者:Xiaohan Ye,Jin Wang,Shengtao Ding,Seyedmorteza Hosseyni,Lukasz Wojtas,Novruz G. Akhmedov,Xiaodong Shi |发布日期:2017.8.4
摘要:From A Gold‐associated Thioketene Intermediate. Based On This Interesting Mechanistic Insight, A Gold(I)‐catalyzed Thioether Addition To Thioalkynes Was Developed As A Novel Approach To Prepare Ketene Dithioacetals With Good Yields And High Efficiency.
合成参考文献
摘要:Sankararaman, S., Science of Synthesis, (2008) 43, 437.
摘要:Negishi, E.; Wang, G., Science of Synthesis, (2009) 46, 246.
摘要:Negishi, E.; Wang, G., Science of Synthesis, (2009) 46, 245.
摘要:Ogasawara, M., Science of Synthesis, (2008) 44, 62.
摘要:Roy, K.-M., Science of Synthesis, (2010) 47, 1140.
📝 需求与反馈
尽可能描述清楚需求与问题信息
