CAS: 7154-66-7; 2-Bromobenzoyl Chloride

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CAS号88-65-3 邻溴苯甲酸 | CAS号79-37-8 草酰氯 | CAS号586-76-5 对溴苯甲酸 | CAS号7719-12-2 三氯化磷 | CAS号118-92-3 邻氨基苯甲酸 | CAS号108-86-1 溴苯 | CAS号54616-47-6 2-溴-N,N-二甲基苯甲酰胺 | CAS号50671-05-1 (2-溴苯甲酰基)乙酸乙酯 | CAS号148836-24-2 (S)-2-(2-溴苯基)-4... | CAS号951883-94-6 2-溴-N-异丙基苯磺酰胺 | CAS号4001-73-4 2-溴苯甲酰胺 | CAS号951883-92-4 2-溴-N-丙基苯磺酰胺 | CAS号1989-22-6 phenyl 2-bromob... | CAS号18595-86-3 2-(2-Bromopheny... | CAS号550-44-7 N-甲基邻苯二甲酰亚胺 | CAS号303991-53-9 N-(3,4-二甲基苯基)-2...

📜2-溴苯甲酸置于氯化亚砜体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以100%的收率获得产物2-溴苯甲酰氯
参考文献:通过铜-联吡啶催化的α-氨基苄基硼酸酯的分子内偶联,在硼结合的立体中心形成立体反转cc键.
标题:通过铜-联吡啶催化的α-氨基苄基硼酸酯的分子内偶联,在硼结合的立体中心形成立体反转cc键.
摘要:通过使用具有2,2'-联吡啶的非手性配体的铜催化剂,可以实现与α-(2-卤代苯甲酰基氨基)苄基硼酸酯的对映体分子内suzuki-Miyaura型偶联,反应生成3-取代的异吲哚啉酮.在具有高对映体特异性的6-苯基-2,2'-联吡啶配体的存在下,在硼结合的立体碳上带有氢原子的对映体富集的α-氨基苄基硼反应物进行立体反转偶联.在存在简单的2,2'-联吡啶作为配体的情况下,带有完全取代的与硼结合的立体成核中心的α-氨基苄基硼酸酯也给出了3,3-二取代的异吲哚啉酮,具有立体定向的立体化学转化作用.
DOI:10.1002/anie.201914864

专利信息

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:US-8748459-B2
优先权日:2002-03-29
标 题 :Pyridinoylpiperidines as 5-HT1F agonists
发明人：COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI
权利人:COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI; LILLY CO ELI
摘要:The present invention relates to compounds of formula I: n nor pharmaceutically acceptable acid addition salts thereof, where;n R 1 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, substituted C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 2 is hydrogen, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 3 alkyl, or a group of formula II nn n n n n n n n n n n n R 3 is hydrogen or C 1 -C 3 alkyl; n R 4 is hydrogen, halo, or C 1 -C 3 alkyl; n R 5 is hydrogen or C 1 -C 3 alkyl; n R 6 is hydrogen or C 1 -C 6 alkyl; and n n is an integer from 1 to 6 inclusively. n n n n n The compounds of the present invention are useful for activating 5-HT lF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:WO-2018191612-A1
优先权日:2017-04-14
标 题 :Synthesis of a phosphorous containing monomer and the incorporation in polycarbonate by interfacial polymerization thereof

专利号:US-6812320-B2
优先权日:2002-03-25
标题:Method for copolyestercarbonate synthesis
发明人：SILVA JAMES MANIO; DARDARIS DAVID MICHEL; O'NEIL GREGORY ALLEN; SYBERT PAUL DEAN; SU ZHAOHUI
权利人:GEN ELECTRIC
摘要:Thermally stable block copolyestercarbonates comprising chain members derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety, said polymer being substantially free of anhydride linkages linking at least two mers of the polyester chain segments, are prepared by a method comprising the steps of: (a) preparing a hydroxy-terminated polyester intermediate comprising structural units derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety; and (b) conducting a reaction of the polyester intermediate with phosgene in a reaction mixture comprising water, a substantially water-immiscible organic solvent, and a base, wherein base and phosgene are added simultaneously to the reaction mixture at a substantially constant molar ratio of base to phosgene for a time period of at least about 60% of the total amount of phosgene added.

专利号:US-2020048410-A1
优先权日:2017-04-14
标 题:Synthesis of a phosphorous containing monomer and the incorporation in polycarbonate by interfacial polymerization thereof