616-05-7 = 625-77-4 + 823-94-9 + 10601-70-4 [标题:Reaction Conditions 标题:High-Temperature Transnitrilation Of 2-Bromocaproic Acid 作者:Polivin,Yu. N.; Et Al 参考文献:Izvestiya Akademii Nauk Sssr 日期:1990 卷标:(7) 页码:1682-4
专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-4892687-A 优先权日:1986-10-08 标题:Process for synthesis of amidoacids using a cobalt catalyst and a bidental phosphine ligand 发明人:LIN JIANG-JEN 权利人:TEXACO INC 摘要:A process is disclosed for producing N-acetyl-aminoacid which comprises reacting a feedstock from the group consisting of simple olefins, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound promoted by a bidental-phosphine ligand in a solvent at a pressure of 500 psi or greater and a temperature of 50 DEG C. or greater. The presence of the ligand increases both reaction rate and cobalt catalyst stability.
专利号:WO-2024258356-A1 优先权日:2023-06-16 标 题 :Isomeric aminophytosphingosines, a method of their production and use 发明人:MARTINKOVA MIROSLAVA; SPAKOVA RASCHMANOVA JANA; NOVOTNA MICHAELA; PONCAKOVA TATIANA; BAGO PILATOVA MARTINA; KESELAKOVA ALEXANDRA; GAL PETER 权利人:UNIVERZITA PAVLA JOZEFA SAFARIKA V KOSICIACH 摘要:Stereoselective synthesis of 3,4-diamino-1,2-diols possessing a long hydrocarbon chain was carried out via olefin cross-metathesis between a commercial tetradec-1-ene and known diastereoisomeric trichloroacetamides prepared in our laboratory. Subsequent modification of the obtained coupling products used an approach based on functional group interconversions, which was accompanied by the rational choice of deprotection protocols. The resulting molecules represent novel isomeric amino analogues of natural D-ribo-phytosphingosine, which on the basis of their structure could have the status of skin sphingomimetics, i.e. substances that can affect the properties of the skin and dermis in terms of improving the quality of the lipid matrix (e.g. change in permeability, hydration), or stimulating the biosynthesis of procollagen in deeper structures. The cytotoxic effect of the prepared aminoisophytosphingosines was examined on two human non-malignant cell lines (BJ and HaCaT) and the screening results confirmed the safety in at least three representatives of the prepared series of compounds. In addition, the ability of the synthesized derivatives to inhibit cancer cell proliferation was also investigated. The results of preliminary anticancer screening showed weaker antiproliferative potential of these unusual sphingoid bases.
专利号:US-4789758-A 优先权日:1985-01-07 标题 :Process for the production of an N-protected-L-α-aspartyl-L-phenylalanine 发明人:TAKEMOTO TADASHI; YUKAWA TOSHIHIDE; HISAMITSU KUNIO 权利人:AJINOMOTO KK 摘要:A process is described for the synthesis of N-protected-L-α-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R 1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R 2 , where R 1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R 2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.
专利号:WO-2025068371-A1 优先权日:2023-09-28 标 题:Inhibitors of the proprotein convertase furin, methods of production thereof and use 发明人:STEINMETZER TORSTEN; LANGE ROMAN WERNER; BOLLER CHARLOTTE; FRIEBERTSHÄUSER EVA; BLOCH KONSTANTIN 权利人:PHILIPPS UNIV MARBURG 摘要:The invention relates to novel inhibitors of the serine protease furin and to related furin-like proprotein convertases according to claim 1, and to methods of synthesis thereof and to use for production of medicaments for treatment of furin-dependent viral and bacterial infection diseases, and other disorders involving furin, such as cystic fibrosis, cancer, osteoarthritis, hypertension, and neurodegenerative disorders.
专利号:US-5236879-A 优先权日:1990-12-06 标 题 :Catalyst for purifying exhaust gas 发明人:INOUE SHUNJI; KASAHARA SENSHI; SEKIZAWA KAZUHIKO 权利人:TOSOH CORP 摘要:A catalyst for purifying an exhaust gas comprising: a crystalline aluminosilicate containing a rare earth or alkaline earth metal produced by allowing a rare earth or alkaline earth metal salt to exist in reactants for a synthesis of a crystalline aluminosilicate, and introduced therein, at least one element selected from the consisting of the group Ib metals and VIII metals of the periodic table.
1: Zhang F, Liu Y, Ma KQ, Yan H, Luo Y, Wu FC, Yang CT, Hu S, Peng SM. Highly selective extraction of uranium from wastewater using amine-bridged diacetamide- functionalized silica. J Hazard Mater. 2022 Aug 5;435:129022. doi: 10.1016/j.jhazmat.2022.129022. Epub 2022 Apr 27. 68(Pt 4):o933. doi: 10.1107/S1600536812008653. Epub 2012 Mar 3. 3: Wang JL. N,N'-Di-8-quinolyl-2,2'-(o-phenyl-ene-di-oxy)diacetamide. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 23;65(Pt 11):o2844. doi: 10.1107/S1600536809041312. 4: Li XF, An Y, Huang QH, Wen YH. N,N-Bis(quinolin-8-yl)-2,2'-[(1,3,4-thia- diazole-2,5-di-yl)bis-(sulfanedi-yl)]diacetamide monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3291. doi: 10.1107/S1600536811047222. Epub 2011 Nov 12.
合成参考文献
参考文献:10.1038/ncomms14226 摘要:Niu L, Yi H, Wang S, Liu T, Liu J, Lei A. Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles. Nature Communications. 2017 Feb 01;8(1):14226. doi: 10.1038/ncomms14226.