CAS: 59468-90-5; 1-Hydroxymidazolam

上下游产品

Midazolam H-benzo[f]imidazo[1,5-a][1,4]diazepine1-acetoxymethyl-8-chloro-(2-fluoro-phenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine H-benzo[f]imidazo[1,5-a][1,4]diazepine-1-carbaldehyde8-chloro-6-(2-fluoro-phenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-1-carbaldehyde 1'-Hydroxymidazolam glucuronide

📜1-乙酰氧基甲基-8-氯-6-(2-氟苯基)-4H-咪唑并[1,5-A][1,4]苯并二氮杂卓置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应生成 1-羟基咪达唑仑
参考文献:Imidazodiazepines And Processes Therefor
标题:Imidazodiazepines And Processes Therefor
摘要:新型咪唑苯二氮杂环己烯和它们的类似物可用作抗癫痫药,肌肉松弛剂,抗焦虑药和镇静剂.该类的优选化合物属于咪唑并[1,5-A][1,4]二氮杂环己烯系列,可能具有非常广泛的有机取代基.在本发明的范围内尤其优选的一类包括式中的化合物,其中 R.Sub.1 为氢和较低的烷基,最好是甲基;r.Sub.3 和 R.Sub.5 为氢;r.Sub.4 为氢,硝基和卤素,最好是氯,在最优选的实施方式中,当位于咪唑苯二氮杂环的融合苯部位的 8-位时,R.Sub.6 为苯基或卤素,硝基或较低烷基取代的苯基,最好是卤素,取代的氟在苯基中的 2-位,R.Sub.2 为氢和较低的烷基.

专利信息

专利号:US-8557981-B2
优先权日:2010-05-04
标题:Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof
发明人：CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA
权利人:CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA; ITALIANA SINT SPA
摘要:The present invention refers to a process for the preparation of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular Midazolam, through an efficient and selective decarboxylation reaction of the derivative compound of the 5-aminomethyl-1-phenyl-1H-imidazole-4-carboxylic acid of formula (II) n navoiding the formation of the 6H-imidazo[1,5-a][1,4]benzodiazepines by-products and the ensuing process for the isomerization of a 4H-imidazo[1,5-a][1,4]benzodiazepine product.

专利号:US-2021062179-A1
优先权日:2015-02-26
标题 :Microsomal bioreactor for synthesis of drug metabolites
发明人：KRISHNAN SADAGOPAN; WALGAMA CHARUKSHA THAMEERA; NERIMETLA RAJASEKHARA REDDY
权利人:UNIV OKLAHOMA STATE
摘要:Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes P 450 (CYPs) and their redox partner proteins, e.g. CYP-NADPH (reduced nicotinamide adenine dinucleotide phosphate) reductases (CPR), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver microsomes (HLM) or as bactosomes, S9 fractions, etc. The bioreactors are used, for example, for synthesizing metabolites of interest from compounds such as drugs that are catabolized by the enzymes.

专利号:US-2011275799-A1
优先权日:2010-05-04
标题:PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF

专利号:IT-MI20100777-A1
优先权日:2010-05-04
标 题 :PROCEDURE FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-A] [1,4] BENZODIAZEPINE, IN PARTICULAR OF MIDAZOLAM.

专利号:IL-212505-A
优先权日:2010-05-04
标题:Process for Synthesis of 4h - Imidazo [5,1– a] [4,1] Benzodiazepines, especially Midazolam and its salts

专利号:CN-103319486-B
优先权日:2012-03-22
标题:Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, especially midazolam