CAS: 54813-77-3; N-Ethyl-N-Isopropylaniline

上下游产品

2-iodo-propane N-ethyl-N-phenylamine N-isopropyl-N-phenyl-acetamide isopropylboronic acidisopropyl-phenyl-carbamonitrile N-isopropylethylamine N-isopropyl-N,N-dimethyl-anilinium; iodideN-isopropyl-N,N-dimethyl-anilinium; iodide 2-(ethyl-isopropyl-amino)-ethanol

📜N-Isopropyl-N-Phenyl-Acetamide置于三乙氧基硅烷,三乙基硼氢化钠体系中,用 正己烷 作为反应溶剂,化学反应 6.0H,以99%的收率获得产物n-乙基-N-异丙苯胺
参考文献:三乙基硼氢化钠催化将未活化的酰胺控制还原为仲胺或叔胺.
标题:三乙基硼氢化钠催化将未活化的酰胺控制还原为仲胺或叔胺.
摘要:建立了第一个无过渡金属的催化方案,该方案使用廉价且稳定的氢化硅烷作为还原剂,可控制地还原酰胺功能.通过改变氢硅烷和溶剂,该新方法能够选择性裂解酰胺中未活化的co键,并使cn键通过脱酰裂解选择性地断裂.总体而言,这种新颖的方法可以为使用化学计量金属系统控制羧酰胺还原的当前方法提供一种通用的替代方法.
DOI:10.1021/acs.Joc.9B02211

专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-6204405-B1
优先权日:1999-12-22
标 题:Economical and convenient procedures for the synthesis of catecholborane
发明人：BROWN HERBERT C
权利人:SIGMA ALDRICH CO
摘要:New, economical and convenient procedures for the preparation of catecholborane in high chemically pure form using tri-O-phenylene bis borate readily prepared from the reaction of catechol with boric acid, and diborane or borane-Lewis base complexes.

专利号:CA-2616058-A1
优先权日:2005-09-08
标题 :Processes for the preparation of (3r,4s)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((s)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe

专利号:WO-2007030721-A9
优先权日:2005-09-08
标 题 :Processes for the preparation of (3r,4s)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((s)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe

专利号:CN-101263111-A
优先权日:2005-09-08
标题:Preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3- Hydroxypropyl)-2-beta-propiolactam, an intermediate for the synthesis of ezetimibe, a method

专利号:EP-2004639-A2
优先权日:2006-04-10
标 题:Processes for the synthesis of azetidinone