CAS: 4562-27-0; Pyrimidin-4(3H)-One

相似化合物

19875-04-8 3524-87-6 66-22-8

上下游产品

CAS号51953-17-4 4-羟基嘧啶 | CAS号66-22-8 尿嘧啶 | CAS号51953-17-4 4-羟基嘧啶 | CAS号51953-18-5 4-羟基嘧啶

嘧啶置于过氧乙酸,硫酸体系中,用 溶剂黄146,丙酮 作为反应溶剂,以9.3%的收率获得产物4(3H)-嘧啶酮
参考文献:Chemistry Of Pyrimidine. Ii. Synthesis Of Pyrimidine N-Oxides And 4-Pyrimidinones By Reaction Of 5-Substituted Pyrimidines With Peracids. Evidence For Covalent Hydrates As Reaction Intermediates
标题:Chemistry Of Pyrimidine. Ii. Synthesis Of Pyrimidine N-Oxides And 4-Pyrimidinones By Reaction Of 5-Substituted Pyrimidines With Peracids. Evidence For Covalent Hydrates As Reaction Intermediates
摘要:
DOI:10.1021/jo00217A012

专利信息

专利号:US-8471010-B2
优先权日:2008-05-13
标题:Synthesis of dihydrothieno[3,2-d]pyrimidine diols
发明人：FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H
权利人:FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.

专利号:WO-2022146324-A1
优先权日:2020-12-29
标 题 :Synthesis of pyrimidine-4(lh)-one derivatives from new hydrazineylidene
发明人：SARIPINAR EMIN; BURCU HILAL JANSET; KEKEÇMUHAMMED HÃœSEYIN; TAPERA MICHAEL
权利人:T C ERCIYES UENIVERSITESI
摘要:This invention relates to the synthesis of pyrimidine-4 (1H)-one derivatives from Meldrum's acid, carbonyl compounds (aldehyde/ketone), and guanylhydrazone derivatives and tautomers, enantiomers, and salts thereof.

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:WO-2024259491-A1
优先权日:2023-06-23
标 题:New synthesis method
发明人：FORD DANIEL; POZNAKS VIKTORS; FOTINS JURIS; ÄŒERÅ…AKS DMITRIJS
权利人:THE HEART RES INSTITUTE LTD
摘要:The present disclosure generally relates to a process for the synthesis of AZD6482. In particular, the present disclosure also relates to a process for the synthesis of enantiomerically pure AZD6482. The present disclosure also relates to a process for the synthesis of enantiomerically pure intermediates. The present disclosure also relates to compounds prepared by the processes and the use of such compounds to prepare compositions and to treat disorders.

专利号:US-2023294064-A1
优先权日:2015-12-28
标 题:Substrates, systems, and methods for nucleic acid array synthesis
发明人：RAJASEKARAN JOHN J
权利人:VIBRANT HOLDINGS LLC
摘要:Disclosed herein are formulations, substrates, and arrays for the synthesis of PNA chains and PNA-DNA chimera on microarrays. In some embodiments, the formulations include a photo-protective compound that shields any PNA monomers, PNA polymers, or PNA-DNA chimera already attached to a microarray from radiation exposure during the synthesis of the PNA or PNA-DNA chains. In some embodiments, substrates and arrays comprise a porous or a planar layer for synthesis and attachment of PNA or DNA monomers, or PNA or PNA-DNA polymers. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of PNA monomers or PNA polymers to a microarray substrate.

专利号:US-12251674-B2
优先权日:2012-11-14
标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
权利人:VIBRANT HOLDINGS LLC
摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.