CAS: 41864-24-8; Tert-Butyl 1H-1,2,4-Triazole-1-Carboxylate

该化合物是有机合成和制药研究中广泛使用的多用途混合环化合物,其关键结构特征是1,2,4-三联苯环所附的三联苯基(Boc)保护组,它加强了稳定性,便利了选择性反应.该组是制作各种生物活性分子的宝贵中间体,特别是在药物发现药用化学中. Boc组在多步合成期间为三联氮提供了极好的保护,同时允许在温和酸条件下容易脱保.其高纯度和定义明确的再活动使得它特别有助于建设复杂的分子结构.该组表明普通有机溶剂的溶性良好,使多种合成协议能够灵活应用.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号288-88-0 1,2,4-三氮唑 | CAS号24424-99-5 二碳酸二叔丁酯

合成工艺路线路线简述

    📜1H-1,2,4-三唑,二碳酸二叔丁酯置于1-Methylimidazolium Tetrafluoroborate体系中,化学反应 1.0H,以78%的收率获得产物1-叔-丁氧基羰基-1,2,4-三唑
    参考文献:An Efficient And Chemoselective Brønsted Acidic Ionic Liquid-Catalyzed N-Boc Protection Of Amines
    标题:An Efficient And Chemoselective Brønsted Acidic Ionic Liquid-Catalyzed N-Boc Protection Of Amines
    摘要:The First Report Of A Bronsted Acidic Ionic Liquid,1-Methylimidazolium Tetrafluoroborate [(Hmim)Bf(4)],Catalyzed Efficient And Chemoselective N-Boc Protection Of Various Amines Using (Boc)(2)O Is Presented. Optically Pure Amino Alcohols And Amino Acid Esters Were Converted Efficiently To Their Corresponding Optically Pure N-Boc Derivatives. The Reported Method Is Mild,Solvent-Free And Has The Advantages Of Both Homogeneous And Heterogeneous Catalysis With High Product Yields,Selectivity And Ease Of Product Separation. (C) 2008 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Tetlet.2008.02.126

    海关参考信息

    专利信息


    专利号:WO-2025027521-A1
    优先权日:2023-08-01
    标题 :An improved process for the preparation of avibactam and intermediate thereof
    发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
    权利人:FRESENIUS KABI ONCOLOGY LTD
    摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.

    专利号:US-12122769-B2
    优先权日:2017-10-19
    标题 :Synthesis of antibacterial aminoglycoside analogs
    发明人：TREND RAISSA; DAPPEN MICHAEL; HENRY CHRISTOPHER E; GOLDBLUM ADAM AARON; AGGEN JAMES BRADLEY; MENDONÇA RICARDO FILIPE DE JESUS GONÇALVES; SARDINHA JOÃO CARLOS FALCÃO
    权利人:CIPLA USA INC
    摘要:The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

    专利号:AU-2022253019-A1
    优先权日:2021-04-09
    标题:Synthesis of rapamycin analog compounds

    专利号:EP-3697797-A1
    优先权日:2017-10-19
    标题 :Synthesis of antibacterial aminoglycoside analogs

    专利号:CN-111655709-A
    优先权日:2017-10-19
    标 题:Synthesis of Antibacterial Aminoglycoside Analogs

    专利号:TW-202304863-A
    优先权日:2021-04-09
    标题:Synthesis of rapamycin analog compounds

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:10.1016/j.tetlet.2008.02.126
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知